Basic Information
ID: ALA4715856
Journal: Bioorg Med Chem
Title: Druggable targets from coronaviruses for designing new antiviral drugs.
Authors: Silva LR,da Silva Santos-Júnior PF,de Andrade Brandão J,Anderson L,Bassi ÊJ,Xavier de Araújo-Júnior J,Cardoso SH,da Silva-Júnior EF
Abstract: Severe respiratory infections were highlighted in the SARS-CoV outbreak in 2002, as well as MERS-CoV, in 2012. Recently, the novel CoV (COVID-19) has led to severe respiratory damage to humans and deaths in Asia, Europe, and Americas, which allowed the WHO to declare the pandemic state. Notwithstanding all impacts caused by Coronaviruses, it is evident that the development of new antiviral agents is an unmet need. In this review, we provide a complete compilation of all potential antiviral agents targeting macromolecular structures from these Coronaviruses (Coronaviridae), providing a medicinal chemistry viewpoint that could be useful for designing new therapeutic agents.
CiteXplore: 33007557
DOI: 10.1016/j.bmc.2020.115745
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets