Investigation on the Anticancer Activity of Symmetric and Unsymmetric Cyclic Sulfamides.
Basic Information
ID: ALA4715923
Journal: ACS Med Chem Lett
Title: Investigation on the Anticancer Activity of Symmetric and Unsymmetric Cyclic Sulfamides.
Authors: Jun JJ,Duscharla D,Ummanni R,Hanson PR,Malhotra SV
Abstract: The sulfamide functional group has been extensively employed in organic synthesis to discover probes and drugs in various applications such as cancer, human immunodeficiency virus (HIV), virus, and diabetes. Herein, we describe the synthesis of 7-membered symmetric and unsymmetric sulfamide compounds and their biological evaluation through the National Cancer Institute (NCI) panel of 60 human tumor cell lines (NCI-60) and the mechanism of action study. The results of a study from the NCI-60 cell line exhibited that many synthesized cyclic sulfamide compounds inhibited breast cancer (MDA-MB-468). The mechanism of action study of a representative compound 18 showed the inhibition of proliferation and apoptosis in A549 lung cancer cells.
CiteXplore: 33603966
DOI: 10.1021/acsmedchemlett.0c00460
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