Anti-inflammatory principles from Lindera aggregata.
Basic Information
ID: ALA4725233
Journal: Bioorg Med Chem Lett
Title: Anti-inflammatory principles from Lindera aggregata.
Authors: Kuo PC,Wu YH,Hung HY,Lam SH,Ma GH,Kuo LM,Hwang TL,Kuo DH,Wu TS
Abstract: Four new sesquiterpenes (1-4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.
CiteXplore: 32359855
DOI: 10.1016/j.bmcl.2020.127224
Patent ID: ┄