Non-'classical' MEKs: A review of MEK3-7 inhibitors.
Basic Information
ID: ALA4725240
Journal: Bioorg Med Chem Lett
Title: Non-'classical' MEKs: A review of MEK3-7 inhibitors.
Authors: Kwong AJ,Scheidt KA
Abstract: The MAPK pathways are an enduring area of interest due to their essential roles in cell processes. Increased expression and activity can lead to a multitude of diseases, sparking research efforts in developing inhibitors against these kinases. Though great strides have been made in developing MEK1/2 inhibitors, there is a notable lack of chemical probes for MEK3-7, given their central role in stimuli response, cell growth, and development. This review summarizes the progress that has been made on developing small molecule probes for MEK3-7, the specific disease states in which they have been studied, and their potential to become novel therapeutics.
CiteXplore: 32389527
DOI: 10.1016/j.bmcl.2020.127203
Patent ID: ┄