Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase.
Basic Information
ID: ALA4725341
Journal: Bioorg Med Chem Lett
Title: Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase.
Authors: Keith JM,Jones W,Pierce JM,Seierstad M,Palmer JA,Webb M,Karbarz M,Scott BP,Wilson SJ,Luo L,Wennerholm M,Chang L,Rizzolio M,Rynberg R,Chaplan S,Guy Breitenbucher J
Abstract: A series of mechanism-based heteroaryl urea fatty acid amide hydrolase (FAAH) inhibitors with fused bicyclic diamine cores is described. In contrast to compounds built around a piperazine core, most of the fused bicyclic diamine bearing analogs prepared exhibited greater potency against rFAAH than the human enzyme. Several compounds equipotent against both species were identified and profiled in vivo.
CiteXplore: 32784090
DOI: 10.1016/j.bmcl.2020.127463
Patent ID: ┄