Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands

Basic Information

ID: ALA4732029

Journal: RSC Med Chem

Title: Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands

Authors: Coban, Tomris, Robertson, Cameron, Schwikkard, Sianne, Singer, Richard, LeGresley, Adam

Abstract: The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.

CiteXplore: 34124673

DOI: 10.1039/d0md00428f

Patent ID: ┄

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