Document Report Card

ID: ALA4811216

Journal: RSC Med Chem

Title: Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?

Authors: Dziwornu GA, Attram HD, Gachuhi S, Chibale K.

Abstract: Globally, schistosomiasis threatens more than 700 million lives, mostly children, in poor localities of tropical and sub-tropical areas with morbidity due to acute and chronic pathological manifestations of the disease. After a century since the first antimonial-based drugs were introduced to treat the disease, anti-schistosomiasis drug development is again at a bottleneck with only one drug, praziquantel, available for treatment purposes. This review focuses on promising chemotypes as potential starting points in a drug discovery effort to meet the urgent need for new schistosomicides.

CiteXplore: 33479649

DOI: 10.1039/D0MD00062K