Novel METTL3 Modulators for Treating Acute Myeloid Leukemia (AML).

ID: ALA4825715

Journal: ACS Med Chem Lett

Title: Novel METTL3 Modulators for Treating Acute Myeloid Leukemia (AML).

Authors: Sabnis RW.

Abstract: Lead optimization in structure-based drug design ultimately requires that the therapeutic agent be evaluated in the cellular context. However, the in vivo control of the target structure remains unyielding to computational modeling. This situation may change as transformer technologies enable a deconstruction of in vivo cooperativity steering drug-induced protein folding.

CiteXplore: 34267869

DOI: 10.1021/acsmedchemlett.1c00280

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