Targeted Isolation of Hemitheion from <i>Mostuea</i> <i>brunonis</i>, a Proposed Biosynthetic Intermediate of Theionbrunonines.
Basic Information
ID: ALA4837190
Journal: J Nat Prod
Title: Targeted Isolation of Hemitheion from Mostuea brunonis, a Proposed Biosynthetic Intermediate of Theionbrunonines.
Authors: Otogo N'Nang E, Le Pogam P, Ndong Mba T, Sima Obiang C, Mouray E, Grellier P, Kumulungui B, Champy P, Beniddir MA.
Abstract: Hemitheion (1), a new sulfur-containing vobasane-type indole alkaloid, was isolated, together with three known compounds, vobasine (2), gelsedine (3), and gelsemicine (4), from the alkaloid extract of the stems of Mostuea brunonis Didr. (Gelsemiaceae). Compound 1 could be straightforwardly isolated. Its structure was elucidated by a combination of spectroscopic methods. Besides corresponding to a formerly postulated biosynthetic intermediate toward theionbrunonines, hemitheion (1) stands among the few monomeric vobasanes lacking an oxygen at C-3. Hemitheion (1) showed moderate antiplasmodial activity in the micromolar range against the strain FcB1 of Plasmodium falciparum and no cytotoxic activity against the MRC-5 cell line at 20 μM.
CiteXplore: 33825474
DOI: 10.1021/acs.jnatprod.1c00143
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