Basic Information
ID: ALA4837209
Journal: Bioorg Med Chem Lett
Title: Synthesis and BK channel-opening activity of 2-amino-1,3-thiazole derivatives.
Authors: Qi XL, Jo H, Wang XY, Ji TT, Lin HX, Park CS, Cui YM.
Abstract: A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring.
CiteXplore: 33964448
DOI: 10.1016/j.bmcl.2021.128083
Patent ID: ┄
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