Targeted Isolation of Saalfelduracin B-D from <i>Amycolatopsis saalfeldensis</i> Using LC-MS/MS-Based Molecular Networking.

Basic Information

ID: ALA4842307

Journal: J Nat Prod

Title: Targeted Isolation of Saalfelduracin B-D from Amycolatopsis saalfeldensis Using LC-MS/MS-Based Molecular Networking.

Authors: Um S, Seibel E, Schalk F, Balluff S, Beemelmanns C.

Abstract: High-resolution tandem mass spectrometry (HR-MS²)-based metabolomic studies of Amycolatopsis saalfeldensis, isolated from the "Saalfelder Feengrotten" caves in Germany, led to the isolation of three ribosomally synthesized and post-translationally modified type II thiopeptides, saalfelduracin B-D (1-3) and the known saalfelduracin A (4). The structures of all four compounds were determined by comparative two-dimensional NMR analysis and high-resolution tandem mass spectrometry.

CiteXplore: 33683882

DOI: 10.1021/acs.jnatprod.0c01027

Patent ID: ┄

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