Data for DCP probe BAY1125976
Basic Information
ID: ALA4879553
Title: Data for DCP probe BAY1125976
Authors: SGC Frankfurt
Abstract: SGC Frankfurt donated chemical probe project: BAY1125976 was donated by Bayer. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY1125976. Control: BAY-940. References: 1. Politz, Oliver, Franziska Siegel, Lars Bärfacker, Ulf Bömer, Andrea Hägebarth, William J. Scott, Martin Michels, Stuart Ince, Roland Neuhaus, Kirstin Meyer, Amaury Ernesto Fernández-Montalván, Ningshu Liu, Franz von Nussbaum, Dominik Mumberg, and Karl Ziegelbauer. 2017. ‘BAY 1125976, a Selective Allosteric AKT1/2 Inhibitor, Exhibits High Efficacy on AKT Signaling-Dependent Tumor Growth in Mouse Models’. International Journal of Cancer 140(2):449–59. PMID: 27699769. 2. Schneeweiss, Andreas, Dagmar Hess, Markus Joerger, Andrea Varga, Stacy Moulder, Apostolia M. Tsimberidou, Cynthia Ma, Sara A. Hurvitz, Christine Rentzsch, Marion Rudolph, Silke Thiele, Oliver Boix, Gary Wilkinson, Eleni Lagkadinou, and Matthias Ocker. 2019. ‘Phase 1 Dose Escalation Study of the Allosteric AKT Inhibitor BAY 1125976 in Advanced Solid Cancer-Lack of Association between Activating AKT Mutation and AKT Inhibition-Derived Efficacy’. Cancers 11(12):E1987. PMID: 31835495 (Secondary paper).
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