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ID: ALA4888484
Title: Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum ,using a nano luciferase reporter read-out
Authors: Dechering K; Duffey M
Abstract: New screening and selection cascade for hit generation of compounds active against the blood stage of Plasmodium falciparum. Screen of the Hit Generation library 1 (HGL1), a library of 141,786 novel compounds, using a robust high throughput screening cascade containing orthogonal efficacy and cytotoxicity assays, including a newly developed and validated nanoluciferase-based assay.