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ID: ALA5053507
Journal: Bioorg Med Chem Lett
Title: Oxadiazepinone HBV capsid assembly modulators.
Authors: Kuduk SD, Stoops B, Lam AM, Espiritu C, Vogel R, Lau V, Klumpp K, Flores OA, Hartman GD.
Abstract: The HBV core protein serves multiple essential functions in the viral life cycle that enable chronic HBV infection to persist, and as such, represents a promising drug target. Modulation of the HBV capsid assembly has shown efficacy in early clinical trials through use of small molecule capsid assembly modulators (CAMs). Herein is described the evolution and SAR of a novel pyrazolo piperidine lead series into advanced oxadiazepinone HBV CAMs.
CiteXplore: 34492302