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ID: ALA5096190

Journal: Eur J Med Chem

Title: Recent advances of quinones as a privileged structure in drug discovery.

Authors: Zhang L, Zhang G, Xu S, Song Y.

Abstract: Privileged structures are conductive to discover novel bioactive substances because they can bind to multiple targets with high affinity. Quinones are considered to be a privileged structure and useful template for the design of new compounds with potential pharmacological activity. This article presents the recent developments (2014-2021 update) of quinones in the fields of antitumor, antibacterial, antifungal, antiviral, anti-Alzheimer's disease (AD) and antimalarial, mainly focusing on biological activities, structural modification and mechanism of action.

CiteXplore: 34153576

DOI: 10.1016/j.ejmech.2021.113632