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ID: ALA5113432

Journal: Bioorg Med Chem Lett

Title: Discovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents.

Authors: Ma J, Jiang Y, Zhuang X, Chen H, Shen Y, Mao Z, Rao G, Wang R.

Abstract: With the widespread use of azole antifungals in the clinic, the drug resistance has been emerging continuously. In this work, we have designed and prepared a series of novel indole and indoline derivatives, and in vitro antifungal activity against C. albicans were evaluated. The results showed that title compounds exhibited good antifungal effect on Azole-resistant C. albicans. Further mechanism study demonstrated that S18 could inhibit the biofilm formation and hyphae growth of C. albicans through the Ras-cAMP-PKA signaling pathway.

CiteXplore: 35661686

DOI: 10.1016/j.bmcl.2022.128826