Ferroptosis Inhibitory Aromatic Abietane Diterpenoids from <i>Ajuga decumbens</i> and Structural Revision of Two 3,4-Epoxy Group-Containing Abietanes.

ID: ALA5120917

Journal: J Nat Prod

Title: Ferroptosis Inhibitory Aromatic Abietane Diterpenoids from Ajuga decumbens and Structural Revision of Two 3,4-Epoxy Group-Containing Abietanes.

Authors: Peng X, Tan Q, Wu L, Wu D, Xu J, Zhou H, Gu Q.

Abstract: Two new 3,4-epoxy group-containing abietane diterpenoids (1 and 2), together with five known diterpenoids (3-7), were isolated from Ajuga decumbens. Their structures were elucidated by spectroscopic data analysis, NMR calculations, and X-ray diffraction experiments. The structures of two known abietane diterpenoids were revised based on NMR calculations and X-ray diffraction data. Notably, compound 4 specifically inhibited RSL3-induced ferroptosis with an EC₅₀ of 56 nM by antioxidation. Moreover, 4 significantly decreased RSL3-induced lipid and cytosolic ROS accumulation and ferroptosis marker gene PTGS2 mRNA expression. This work reports the most potent natural inhibitor against ferroptosis found so far.

CiteXplore: 35796002

DOI: 10.1021/acs.jnatprod.2c00352

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