Basic Information
ID: ALA5126655
Journal: J Nat Prod
Title: Koshidacins A and B, Antiplasmodial Cyclic Tetrapeptides from the Okinawan Fungus Pochonia boninensis FKR-0564.
Authors: Watanabe Y, Hachiya K, Ikeda A, Nonaka K, Higo M, Muramatsu R, Noguchi C, Honsho M, Asami Y, Inahashi Y, Hirose T, Matsui H, Sunazuka T, Hanaki H, Ishii T, Teruya T, Hokari R, Ishiyama A, Iwatsuki M.
Abstract: Two new antiplasmodial peptides, named koshidacins A (1) and B (2), were discovered from the culture broth of the Okinawan fungus Pochonia boninensis FKR-0564. Their structures, including absolute configurations, were elucidated by a combination of spectroscopic methods and chemical derivatization. Both compounds showed moderate in vitro antiplasmodial activity against Plasmodium falciparum strains, with IC50 values ranging from 17.1 to 0.83 μM. In addition, compound 2 suppressed 41% of malaria parasites in vivo when administered intraperitoneally at a dose of 30 mg/kg/day for 4 days.
CiteXplore: 36282784
DOI: 10.1021/acs.jnatprod.2c00719
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets