Document Report Card

ID: ALA5136971

Journal: RSC Med Chem

Title: Virtual screening and in vitro validation identifies the first reported inhibitors of Salmonella enterica HPPK.

Authors: Müller R, Gerwel TM, Kimuda MP, Bishop ÖT, Veale CGL, Hoppe HC.

Abstract: HPPK, which directly precedes DHPS in the folate biosynthetic pathway, is a promising but chronically under-exploited anti-microbial target. Here we report the identification of new S. enterica HPPK inhibitors, offering potential for new resistance circumventing S. enterica therapies as well as avenues for diversifying the current HPPK inhibitor space.

CiteXplore: 34778775

DOI: 10.1039/D1MD00237F