Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases.
Basic Information
ID: ALA5149965
Journal: J Med Chem
Title: Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases.
Authors: Xie Z, Yang X, Duan Y, Han J, Liao C.
Abstract: Great successes have been achieved in developing small-molecule kinase inhibitors as anticancer therapeutic agents. However, kinase deregulation plays essential roles not only in cancer but also in almost all major disease areas. Accumulating evidence has revealed that kinases are promising drug targets for different diseases, including cancer, autoimmune diseases, inflammatory diseases, cardiovascular diseases, central nervous system disorders, viral infections, and malaria. Indeed, the first small-molecule kinase inhibitor for treatment of a nononcologic disease was approved in 2011 by the U.S. FDA. To date, 10 such inhibitors have been approved, and more are in clinical trials for applications other than cancer. This Perspective discusses a number of kinases and their small-molecule inhibitors for the treatment of diseases in nononcologic therapeutic fields. The opportunities and challenges in developing such inhibitors are also highlighted.
CiteXplore: 33481605
DOI: 10.1021/acs.jmedchem.0c01511
Patent ID: ┄