Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents.
Basic Information
ID: ALA5154865
Journal: Eur J Med Chem
Title: Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents.
Authors: Shingare RD, MacMillan JB, Reddy DS.
Abstract: Design and synthesis of library of compounds around the antibiotic natural product hunanamycin A scaffold and their biological evaluation are disclosed here. These efforts resulted in identification of a lead compound 36, which is a structurally simplified analogue of original hunanamycin A with impressive activity against Salmonella enterica and possesses other druggable properties. In addition, no acute oral toxicity was observed for compound 36 in Swiss albino mice dosed up to 2 g/kg. It has the potential to be developed for the treatment of food infections caused by Salmonella.
CiteXplore: 35421661
DOI: 10.1016/j.ejmech.2022.114245
Patent ID: ┄