Document Report Card
Basic Information
ID: ALA5226373
Journal: J Nat Prod
Title: Dichapetalins from the Twigs of Dichapetalum longipetalum with Cytotoxic Activities.
Authors: Zhou B, Gao XH, Zhang MM, Liu HC, Yue JM.
Abstract: Continued efforts to expand the structural diversity of dichapetalins and explore further the cytotoxic structure-activity relationships have led to the isolation of 17 undescribed analogues, dichapelonins A-Q (1-17), and three known compounds (18-20) from the twigs of Dichapetalum longipetalum. Compounds 1-17 comprise five compound classes as classified by varied C6-C2 conjugates at the A ring of the 13,30-cyclodammarane skeleton, and their structures were determined by spectroscopic data analysis, experimental electronic circular dichroism measurements, and X-ray crystallography. Biological tests revealed compounds 1-7 with a phenyl-butadiene appendage to be the most potent cytotoxic compound type of those evaluated.
CiteXplore: 36583957