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ID: ALA5226373

Journal: J Nat Prod

Title: Dichapetalins from the Twigs of Dichapetalum longipetalum with Cytotoxic Activities.

Authors: Zhou B, Gao XH, Zhang MM, Liu HC, Yue JM.

Abstract: Continued efforts to expand the structural diversity of dichapetalins and explore further the cytotoxic structure-activity relationships have led to the isolation of 17 undescribed analogues, dichapelonins A-Q (1-17), and three known compounds (18-20) from the twigs of Dichapetalum longipetalum. Compounds 1-17 comprise five compound classes as classified by varied C6-C2 conjugates at the A ring of the 13,30-cyclodammarane skeleton, and their structures were determined by spectroscopic data analysis, experimental electronic circular dichroism measurements, and X-ray crystallography. Biological tests revealed compounds 1-7 with a phenyl-butadiene appendage to be the most potent cytotoxic compound type of those evaluated.

CiteXplore: 36583957

DOI: 10.1021/acs.jnatprod.2c00971