Peniandranoids A-E: Meroterpenoids with Antiviral and Immunosuppressive Activity from a <i>Penicillium</i> sp.

ID: ALA5226374

Journal: J Nat Prod

Title: Peniandranoids A-E: Meroterpenoids with Antiviral and Immunosuppressive Activity from a Penicillium sp.

Authors: Chang JL, Gan YT, Peng XG, Ouyang QX, Pei J, Ruan HL.

Abstract: Peniandranoids A-E (1-5), five new meroterpenoids, together with three known analogues (6-8), were isolated from the fermentation of a soil-derived fungus, Penicillium sp.sb62. Their structures including absolute configurations were determined by extensive spectroscopic analysis, and the absolute configurations of compounds 1 and 5 were further elucidated by single-crystal X-ray diffraction. Peniandranoids A-E belong to a rare class of andrastin-type meroterpenoids incorporating an extra polyketide unit (a C₁₀ polyketide unit for 1 and 2, a C₉ polyketide unit for 3 and 4, and a furancarboxylic acid unit for 5). Compounds 1 and 6 exhibited favorable inhibitory activities against influenza virus A (H1N1) with EC₅₀ values of 19 and 14 μg/mL, respectively. Compounds 3-8 exhibited potent immunosuppressive activities against concanavalin A-induced T cell proliferation with EC₅₀ values ranging from 4.3 to 27 μM and lipopolysaccharide-induced B cell proliferation with EC₅₀ values ranging from 7.5 to 23 μM, respectively.

CiteXplore: 36596229

DOI: 10.1021/acs.jnatprod.2c00766

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