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ID: ALA5230151
Journal: Eur J Med Chem
Title: A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective.
Authors: Wang J, Gong F, Liang T, Xie Z, Yang Y, Cao C, Gao J, Lu T, Chen X.
Abstract: 1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural products (NPs) and synthetic compounds which show a variety of pharmacological activities. In this article, we reviewed the design, structures and biological characteristics of reported synthetic THβC compounds, and structure and activity relationship (SAR) of them were also discussed. This work might provide a reference for subsequent drug development based on THβC.
CiteXplore: 34479038