Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents.
Basic Information
ID: ALA5233283
Journal: Bioorg Med Chem
Title: Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents.
Authors: Hong Y, Zhu YY, He Q, Gu SX.
Abstract: The α- and β-tubulins are the major polypeptide components of microtubules (MTs), which are attractive targets for anticancer drug development. Indole derivatives display a variety of biological activities including antitumor activity. In recent years, a great number of indole derivatives as tubulin polymerization inhibitors have sprung up, which encourages medicinal chemists to pursue promising inhibitors with improved antitumor activities, excellent physicochemical, pharmacokinetic and pharmacodynamic properties. In this review, the recent progress from 2010 to present in the development of indole derivatives as tubulin polymerization inhibitors was summarized and reviewed, which would provide useful clues and inspirations for further design of outstanding tubulin polymerization inhibitors.
CiteXplore: 34995858
DOI: 10.1016/j.bmc.2021.116597
Patent ID: ┄