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ID: ALA5236573
Journal: Bioorg Med Chem Lett
Title: Development of benzodioxine-heteroarylpiperazines as highly potent and selective α2c antagonists.
Authors: Wang S, Haikarainen A, Pohjakallio A, Sipilä J, Kaskinoro J, Juhila S, Jalava N, Koskinen M, Vesajoki M, Kumpulainen E, Pystynen J, Koskelainen T, Holm P, Din Belle D.
Abstract: Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candidate molecules.
CiteXplore: 36174834