Synthesis of 1-O-acyl- and 1-oxo-kamebanin analogues and their cytotoxic activity.

ID: ALA5241128

Journal: Bioorg Med Chem Lett

Title: Synthesis of 1-O-acyl- and 1-oxo-kamebanin analogues and their cytotoxic activity.

Authors: Aoyagi Y, Tomita K, Kobayashi A, Nakamura A, Fujii Y, Yagi M, Ichimaru Y, Ozawa K, Park HS, Fukaya H, Yano R, Hasuda T, Takeya K, Hitotsuyanagi Y, Gui MY, Jin YR, Li XW.

Abstract: A series of 1-O-acyl- and 1-oxo-kamebanin analogues were prepared from kamebanin, isolated from Rabdosia excisa and their cytotoxicity was assayed on HL60 promyelocytic leukemia cells and HCT116 human colon cancer cells. The structure-activity relationship study showed that the presence of 1-O-acyl groups of a C₃-C₅ carbon chain increased the cytotoxic activity.

CiteXplore: 36690039

DOI: 10.1016/j.bmcl.2023.129149

Patent ID: ┄