Bioassay-Guided Isolation of Fungistatic Compounds from <i>Mimosa caesalpiniifolia</i> Leaves.

ID: ALA5244225

Journal: J Nat Prod

Title: Bioassay-Guided Isolation of Fungistatic Compounds from Mimosa caesalpiniifolia Leaves.

Authors: Dias Silva MJ, Simonet AM, Silva NC, Dias ALT, Vilegas W, Macías FA.

Abstract: A bioassay-guided phytochemical study of a Mimosa caesalpiniifolia leaf extract with antifungal activity permitted the identification of 28 compounds, including the new 6-(β-boivinopyranosyl)apigenin (1), 8-(β-oliopyranosyl)apigenin (2), (E)-6-(2-carboxyethenyl)apigenin (3), (E)-8-(2-carboxyethenyl)apigenin (4), and 7,5″-anhydro-6-(α-2,6-dideoxy-5-hydroxyarabinohexopyranosyl)apigenin (5). The structures of the new compounds were determined by comprehensive spectroscopic analysis, including 1D and 2D NMR techniques, and by mass spectrometry. Compound 3 showed promising activity and selectivity against Candida krusei (IC₅₀ 44 nM), which exhibits resistance to azoles. The association of the major components 3-β-d-glucopyranosyloxysitosterol (8) and ethyl gallate (10) was synergistic against C. krusei, especially the IC values of compound 10, which were reduced by more than 100-fold.

CiteXplore: 31244146

DOI: 10.1021/acs.jnatprod.8b01025

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