Basic Information
ID: ALA5257067
Journal: Bioorg Med Chem Lett
Title: Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS.
Authors: Dodd CJ, Chronister KS, Rathnayake U, Parr LC, Li K, Chang S, Mi D, Days EL, Bauer JA, Cho HP, Boutaud O, Denton JS, Lindsley CW, Han C.
Abstract: Kir6.2/SUR1 is an ATP-regulated potassium channel that acts as an intracellular metabolic sensor, controlling insulin and appetite-stimulatory neuropeptides secretion. In this Letter, we present the SAR around a novel Kir6.2/SUR1 channel opener scaffold derived from an HTS screening campaign. New series of compounds with tractable SAR trends and favorable potencies are reported.
CiteXplore: 36966977
DOI: 10.1016/j.bmcl.2023.129256
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets