Document Report Card
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ID: ALA5303768
Title: Data for DCP probe TP-060
Authors: SGC Frankfurt
Abstract: SGC Frankfurt donated chemical probe project: TP-060 was donated by Takeda. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/TP-060. Control: TP-060n. References: 1. Tanaka, Yuta, Masaki Seto, Keiko Kakegawa, Kazuaki Takami, Fumiaki Kikuchi, Takeshi Yamamoto, Minoru Nakamura, Masaki Daini, Masataka Murakami, Tomohiro Ohashi, Takahito Kasahara, Junsi Wang, Zenichi Ikeda, Yasufumi Wada, Florian Puenner, Takahiro Fujii, Masakazu Inazuka, Sho Sato, Tomohiko Suzaki, Jeong-Ho Oak, Yuichi Takai, Hiroshi Kohara, Kouya Kimoto, Hideyuki Oki, Satoshi Mikami, Minoru Sasaki, and Yuta Tanaka. 2022. ‘Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore’. Journal of Medicinal Chemistry 65(5):4270–90. PMID: 35188773 (T-036). 2. Fujii, Takahiro, Yuta Tanaka, Hideyuki Oki, Sho Sato, Sachio Shibata, Takamitsu Maru, Yuta Tanaka, Maiko Tanaka, and Tomohiro Onishi. 2021. ‘A New Brain-Penetrant Glucosylceramide Synthase Inhibitor as Potential Therapeutics for Gaucher Disease’. Journal of Neurochemistry 159(3):543–53. PMID: 34398463 (T-036). 3. Wang, Junsi, Matthew Reynolds, Ignacio Ibáñez, Yusuke Sasaki, Yuta Tanaka, Fumiaki Kikuchi, Tomohiro Ohashi, Sho Sato, Mariko Miyabayashi, Takahiro Fujii, and Yuta Tanaka. 2022. ‘Photoredox-Based Late-Stage Functionalization in SAR Study for in Vivo Potent Glucosylceramide Synthase Inhibitor’. Bioorganic & Medicinal Chemistry Letters 77:129039. PMID: 36341811 (T-036).