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ID: ALA5303769
Title: Data for DCP probe JNJ-42226314
Authors: SGC Frankfurt
Abstract: SGC Frankfurt donated chemical probe project: JNJ-42226314 was donated by Janssen. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-42226314. Control: JNJ-8034. References: 1. Wyatt, Ryan M., Ian Fraser, Natalie Welty, Brian Lord, Michelle Wennerholm, Steven Sutton, Michael K. Ameriks, Christine Dugovic, Sujin Yun, Allison White, Leslie Nguyen, Tatiana Koudriakova, Gaochao Tian, Javier Suarez, Lawrence Szewczuk, William Bonnette, Kay Ahn, Brahma Ghosh, Christopher M. Flores, Peter J. Connolly, Bin Zhu, Mark J. Macielag, Michael R. Brandt, Kristen Chevalier, Sui-Po Zhang, Timothy Lovenberg, and Pascal Bonaventure. 2020. ‘Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)Indol-5-Yl]-[3-[4-(Thiazole-2-Carbonyl)Piperazin-1-Yl]Azetidin-1-Yl]Methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor’. The Journal of Pharmacology and Experimental Therapeutics 372(3):339–53. PMID: 31818916. 2. Zhu, Bin, Peter J. Connolly, Yue-Mei Zhang, Mark E. McDonnell, Haiyan Bian, Shu-Chen Lin, Li Liu, Sui-Po Zhang, Kristen M. Chevalier, Michael R. Brandt, Cynthia M. Milligan, Christopher M. Flores, and Mark J. Macielag. 2020. ‘The Discovery of Azetidine-Piperazine Di-Amides as Potent, Selective and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors’. Bioorganic & Medicinal Chemistry Letters 30(14):127243. PMID: 32527545 (compund 6g).