Cystine/glutamate transporter
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ID: ALA1075149
Type: SINGLE PROTEIN
Synonyms: Amino acid transport system xc- | Calcium channel blocker resistance protein CCBR1 | Cystine/glutamate transporter | SLC7A11 | Solute carrier family 7 member 11 | xCT
Organism: Homo sapiens
Species Group: Homo sapiens
Protein Target Classification: Transporter / Electrochemical transporter / SLC superfamily of solute carriers / SLC03 and SLC07 families of heteromeric amino acid transporters (HATs) / SLC07 Cationic amino acid transporter/glycoprotein-associated family
Description | Relationship | Accession |
---|---|---|
Cystine/glutamate transporter | PROTEIN | Q9UPY5 |
Name:
3,4-dimethyl-6-p-tolylisoxazolo[3,4-d]pyridazin-7(6H)-one
Mol. Formula:
C14H13N3O2
M.W.:
255.28
Type:
Small molecule
AlogP:
2.30
Polar Surface Area:
60.92
HBA:
5
HBD:
0
#RO5 Violations:
0
#Rotatable Bonds:
1
Passes Ro3:
N
QED Weighted:
0.67
Name:
6-(2,4-difluorophenyl)-3,4-dimethylisoxazolo[3,4-d]pyridazin-7(6H)-one
Mol. Formula:
C13H9F2N3O2
M.W.:
277.23
Type:
Small molecule
AlogP:
2.27
Polar Surface Area:
60.92
HBA:
5
HBD:
0
#RO5 Violations:
0
#Rotatable Bonds:
1
Passes Ro3:
N
QED Weighted:
0.68
Name:
6-(4-methoxyphenyl)-3,4-dimethylisoxazolo[3,4-d]pyridazin-7(6H)-one
Mol. Formula:
C14H13N3O3
M.W.:
271.28
Type:
Small molecule
AlogP:
2.00
Polar Surface Area:
70.15
HBA:
6
HBD:
0
#RO5 Violations:
0
#Rotatable Bonds:
2
Passes Ro3:
N
QED Weighted:
0.71
Name:
6-(3,5-bis(trifluoromethyl)phenyl)-3,4-dimethylisoxazolo[3,4-d]pyridazin-7(6H)-one
Mol. Formula:
C15H9F6N3O2
M.W.:
377.24
Type:
Small molecule
AlogP:
4.03
Polar Surface Area:
60.92
HBA:
5
HBD:
0
#RO5 Violations:
0
#Rotatable Bonds:
1
Passes Ro3:
N
QED Weighted:
0.60
Name:
6-(3,5-dichlorophenyl)-3,4-dimethylisoxazolo[3,4-d]pyridazin-7(6H)-one
Mol. Formula:
C13H9Cl2N3O2
M.W.:
310.14
Type:
Small molecule
AlogP:
3.30
Polar Surface Area:
60.92
HBA:
5
HBD:
0
#RO5 Violations:
0
#Rotatable Bonds:
1
Passes Ro3:
N
QED Weighted:
0.69
Name:
(E)-ethyl 5-methyl-4-(1-(2-(phenylsulfonyl)hydrazono)ethyl)isoxazole-3-carboxylate
Mol. Formula:
C15H17N3O5S
M.W.:
351.38
Type:
Small molecule
AlogP:
1.86
Polar Surface Area:
110.86
HBA:
7
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
6
Passes Ro3:
N
QED Weighted:
0.48
Name:
S)-4-(2-amino-2-carboxyethyl)-5-methylisoxazole-3-carboxylic acid
Mol. Formula:
C8H10N2O5
M.W.:
214.18
Type:
Small molecule
AlogP:
-0.36
Polar Surface Area:
126.65
HBA:
5
HBD:
3
#RO5 Violations:
0
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.62
Name:
(S)-4-(2-amino-2-carboxyethyl)-5-ethylisoxazole-3-carboxylic acid
Mol. Formula:
C9H12N2O5
M.W.:
228.20
Type:
Small molecule
AlogP:
-0.11
Polar Surface Area:
126.65
HBA:
5
HBD:
3
#RO5 Violations:
0
#Rotatable Bonds:
5
Passes Ro3:
N
QED Weighted:
0.64
Name:
4-((S)-2-amino-2-carboxyethyl)-5-(1-methoxyethyl)isoxazole-3-carboxylic acid
Mol. Formula:
C10H14N2O6
M.W.:
258.23
Type:
Small molecule
AlogP:
0.03
Polar Surface Area:
135.88
HBA:
6
HBD:
3
#RO5 Violations:
0
#Rotatable Bonds:
6
Passes Ro3:
N
QED Weighted:
0.65
Name:
4-[(2R,S)-2-Amino-2-carboxyethyl]-5-[benzyloxymethyl]isoxazole-3-carboxylic acid
Mol. Formula:
C15H16N2O6
M.W.:
320.30
Type:
Small molecule
AlogP:
1.04
Polar Surface Area:
135.88
HBA:
6
HBD:
3
#RO5 Violations:
0
#Rotatable Bonds:
8
Passes Ro3:
N
QED Weighted:
0.66