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Cystine/glutamate transporter

Name And Classification

ID:  ALA1075149

Type:  SINGLE PROTEIN

Synonyms:   Amino acid transport system xc- | Calcium channel blocker resistance protein CCBR1 | Cystine/glutamate transporter | SLC7A11 | Solute carrier family 7 member 11 | xCT

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Transporter / Electrochemical transporter / SLC superfamily of solute carriers / SLC03 and SLC07 families of heteromeric amino acid transporters (HATs) / SLC07 Cationic amino acid transporter/glycoprotein-associated family

Target Components

DescriptionRelationshipAccession
Cystine/glutamate transporterPROTEINQ9UPY5

Associated Active Ligands

  1. Tetrahydrouridine
    ALA591731

    Name:
    3,4-dimethyl-6-p-tolylisoxazolo[3,4-d]pyridazin-7(6H)-one

    Mol. Formula:
    C14H13N3O2

    M.W.:
    255.28

    Type:
    Small molecule

    AlogP:
    2.30

    Polar Surface Area:
    60.92

    HBA:
    5

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    N

    QED Weighted:
    0.67

    DETAILS
  2. Tetrahydrouridine
    ALA602348

    Name:
    6-(2,4-difluorophenyl)-3,4-dimethylisoxazolo[3,4-d]pyridazin-7(6H)-one

    Mol. Formula:
    C13H9F2N3O2

    M.W.:
    277.23

    Type:
    Small molecule

    AlogP:
    2.27

    Polar Surface Area:
    60.92

    HBA:
    5

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    N

    QED Weighted:
    0.68

    DETAILS
  3. Tetrahydrouridine
    ALA591732

    Name:
    6-(4-methoxyphenyl)-3,4-dimethylisoxazolo[3,4-d]pyridazin-7(6H)-one

    Mol. Formula:
    C14H13N3O3

    M.W.:
    271.28

    Type:
    Small molecule

    AlogP:
    2.00

    Polar Surface Area:
    70.15

    HBA:
    6

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.71

    DETAILS
  4. Tetrahydrouridine
    ALA590303

    Name:
    6-(3,5-bis(trifluoromethyl)phenyl)-3,4-dimethylisoxazolo[3,4-d]pyridazin-7(6H)-one

    Mol. Formula:
    C15H9F6N3O2

    M.W.:
    377.24

    Type:
    Small molecule

    AlogP:
    4.03

    Polar Surface Area:
    60.92

    HBA:
    5

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    N

    QED Weighted:
    0.60

    DETAILS
  5. Tetrahydrouridine
    ALA600652

    Name:
    6-(3,5-dichlorophenyl)-3,4-dimethylisoxazolo[3,4-d]pyridazin-7(6H)-one

    Mol. Formula:
    C13H9Cl2N3O2

    M.W.:
    310.14

    Type:
    Small molecule

    AlogP:
    3.30

    Polar Surface Area:
    60.92

    HBA:
    5

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    N

    QED Weighted:
    0.69

    DETAILS
  6. Tetrahydrouridine
    ALA602723

    Name:
    (E)-ethyl 5-methyl-4-(1-(2-(phenylsulfonyl)hydrazono)ethyl)isoxazole-3-carboxylate

    Mol. Formula:
    C15H17N3O5S

    M.W.:
    351.38

    Type:
    Small molecule

    AlogP:
    1.86

    Polar Surface Area:
    110.86

    HBA:
    7

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.48

    DETAILS
  7. Tetrahydrouridine
    ALA602962

    Name:
    S)-4-(2-amino-2-carboxyethyl)-5-methylisoxazole-3-carboxylic acid

    Mol. Formula:
    C8H10N2O5

    M.W.:
    214.18

    Type:
    Small molecule

    AlogP:
    -0.36

    Polar Surface Area:
    126.65

    HBA:
    5

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.62

    DETAILS
  8. Tetrahydrouridine
    ALA602640

    Name:
    (S)-4-(2-amino-2-carboxyethyl)-5-ethylisoxazole-3-carboxylic acid

    Mol. Formula:
    C9H12N2O5

    M.W.:
    228.20

    Type:
    Small molecule

    AlogP:
    -0.11

    Polar Surface Area:
    126.65

    HBA:
    5

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.64

    DETAILS
  9. Tetrahydrouridine
    ALA589116

    Name:
    4-((S)-2-amino-2-carboxyethyl)-5-(1-methoxyethyl)isoxazole-3-carboxylic acid

    Mol. Formula:
    C10H14N2O6

    M.W.:
    258.23

    Type:
    Small molecule

    AlogP:
    0.03

    Polar Surface Area:
    135.88

    HBA:
    6

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.65

    DETAILS
  10. Tetrahydrouridine
    ALA591745

    Name:
    4-[(2R,S)-2-Amino-2-carboxyethyl]-5-[benzyloxymethyl]isoxazole-3-carboxylic acid

    Mol. Formula:
    C15H16N2O6

    M.W.:
    320.30

    Type:
    Small molecule

    AlogP:
    1.04

    Polar Surface Area:
    135.88

    HBA:
    6

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.66

    DETAILS