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Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha

Name And Classification

ID:  ALA1795194

Type:  SINGLE PROTEIN

Synonyms:   1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha | 2.7.1.149 | Diphosphoinositide kinase 2-alpha | Phosphatidylinositol 5-Phosphate 4-Kinase | Phosphatidylinositol 5-phosphate 4-kinase type II alpha | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | PI(5)P 4-kinase type II alpha | PI5P4Kalpha | PIP4K2A | PIP4KII-alpha | PIP5K2 | PIP5K2A | PIP5KIII | PtdIns(4)P-5-kinase B isoform | PtdIns(4)P-5-kinase C isoform | PtdIns(5)P-4-kinase isoform 2-alpha | Synonyms=PI5P4KA

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Transferase

Target Components

DescriptionRelationshipAccession
Phosphatidylinositol 5-phosphate 4-kinase type-2 alphaPROTEINP48426

Associated Active Ligands

  1. Tetrahydrouridine
    ALA3186393

    Name:
    SID103163323

    Mol. Formula:
    C15H17FN4O4S

    M.W.:
    368.39

    Type:
    Small molecule

    AlogP:
    1.18

    Polar Surface Area:
    116.60

    HBA:
    7

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.63

    DETAILS
  2. Tetrahydrouridine
    ALA4436057

    Name:
    (Z)-N-(4-(6-Amino-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

    Mol. Formula:
    C16H15N5O3S2

    M.W.:
    389.46

    Type:
    Unknown

    AlogP:
    1.84

    Polar Surface Area:
    138.03

    HBA:
    7

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.59

    DETAILS
  3. Tetrahydrouridine
    ALA4439287

    Name:
    4-[[(E)-4-(dimethylamino)but-2-enoyl]amino]-N-[3-[[7-(p-tolyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]phenyl]benzamide

    Mol. Formula:
    C32H31N7O2

    M.W.:
    545.65

    Type:
    Unknown

    AlogP:
    5.78

    Polar Surface Area:
    104.18

    HBA:
    7

    HBD:
    3

    #RO5 Violations:
    2

    #Rotatable Bonds:
    9

    Passes Ro3:
    N

    QED Weighted:
    0.20

    DETAILS
  4. Tetrahydrouridine
    ALA4441998

    Name:
    (Z)-5-((5-(4-Fluorophenyl)pyridin-3-yl)methylene)-2-iminothiazolidin-4-one

    Mol. Formula:
    C15H10FN3OS

    M.W.:
    299.33

    Type:
    Unknown

    AlogP:
    3.03

    Polar Surface Area:
    65.84

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.84

    DETAILS
  5. Tetrahydrouridine
    ALA4443959

    Name:
    (Z)-2-Imino-5-((5-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)methylene)thiazolidin-4-one

    Mol. Formula:
    C16H10F3N3O2S

    M.W.:
    365.34

    Type:
    Unknown

    AlogP:
    3.79

    Polar Surface Area:
    75.07

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.81

    DETAILS
  6. Tetrahydrouridine
    ALA4446338

    Name:
    4-[[4-(dimethylamino)but-2-enoyl]amino]-N-[3-[[6-(1H-indol-3-yl)pyrimidin-4-yl]amino]phenyl]benzamide

    Mol. Formula:
    C31H29N7O2

    M.W.:
    531.62

    Type:
    Unknown

    AlogP:
    5.68

    Polar Surface Area:
    115.04

    HBA:
    6

    HBD:
    4

    #RO5 Violations:
    2

    #Rotatable Bonds:
    9

    Passes Ro3:
    N

    QED Weighted:
    0.18

    DETAILS
  7. Tetrahydrouridine
    ALA4449493

    Name:
    (E)-4-(dimethylamino)-N-[1-[2-[3-[[6-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrimidin-4-yl]amino]phenyl]acetyl]-4-piperidyl]but-2-enamide

    Mol. Formula:
    C30H34N8O2

    M.W.:
    538.66

    Type:
    Unknown

    AlogP:
    3.53

    Polar Surface Area:
    119.14

    HBA:
    7

    HBD:
    3

    #RO5 Violations:
    1

    #Rotatable Bonds:
    9

    Passes Ro3:
    N

    QED Weighted:
    0.28

    DETAILS
  8. Tetrahydrouridine
    ALA4454033

    Name:
    (Z)-N-(4-(2-Amino-5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)pyridin-3-yl)phenyl)methanesulfonamide

    Mol. Formula:
    C16H15N5O3S2

    M.W.:
    389.46

    Type:
    Unknown

    AlogP:
    1.84

    Polar Surface Area:
    138.03

    HBA:
    7

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.59

    DETAILS
  9. Tetrahydrouridine
    ALA4454740

    Name:
    4-[[(E)-4-(dimethylamino)but-2-enoyl]amino]-N-[3-[[6-(2-methylindazol-5-yl)pyrimidin-4-yl]amino]phenyl]benzamide

    Mol. Formula:
    C31H30N8O2

    M.W.:
    546.64

    Type:
    Unknown

    AlogP:
    5.08

    Polar Surface Area:
    117.07

    HBA:
    8

    HBD:
    3

    #RO5 Violations:
    2

    #Rotatable Bonds:
    9

    Passes Ro3:
    N

    QED Weighted:
    0.22

    DETAILS
  10. Tetrahydrouridine
    ALA4459957

    Name:
    (Z)-2-Imino-5-((5-(4-methoxynaphthalen-1-yl)pyridin-3-yl)methylene)thiazolidin-4-one

    Mol. Formula:
    C20H15N3O2S

    M.W.:
    361.43

    Type:
    Unknown

    AlogP:
    4.05

    Polar Surface Area:
    75.07

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.69

    DETAILS