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Serotonin 3a (5-HT3a) receptor

Name And Classification

ID:  ALA1899

Type:  SINGLE PROTEIN

Synonyms:   5-HT-3 | 5-HT3-A | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 | 5-hydroxytryptamine receptor 3A | 5HT3R | HTR3 | HTR3A | Serotonin receptor 3A | Serotonin-gated ion channel receptor

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Ion channel / Ligand-gated ion channel / 5HT3 receptor

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA4296091SUBSET OF5-hydroxytryptamine receptor 3A/3CPROTEIN COMPLEX
ALA2111332SUBSET OFSerotonin 3 (5-HT3) receptorPROTEIN COMPLEX
ALA2096904SUBSET OFSerotonin (5-HT) receptorPROTEIN FAMILY
ALA2094132SUBSET OFSerotonin 3 (5-HT3) receptorPROTEIN COMPLEX GROUP
ALA4296087SUBSET OF5-hydroxytryptamine receptor 3A/3EPROTEIN COMPLEX

Target Components

DescriptionRelationshipAccession
5-hydroxytryptamine receptor 3APROTEINP46098

Associated Active Ligands

  1. Tetrahydrouridine
    ALA28992

    Name:
    4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-((S)-methoxy)-benzamide

    Mol. Formula:
    C15H20ClN3O2

    M.W.:
    309.80

    Type:
    Small molecule

    AlogP:
    1.75

    Polar Surface Area:
    67.59

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.83

    DETAILS
  2. Tetrahydrouridine
    ALA41543

    Name:
    10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide

    Mol. Formula:
    C15H14N2O

    M.W.:
    238.29

    Type:
    Small molecule

    AlogP:
    3.00

    Polar Surface Area:
    46.33

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    0

    Passes Ro3:
    N

    QED Weighted:
    0.75

    DETAILS
  3. Tetrahydrouridine
    ALA38465

    Name:
    2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiazole

    Mol. Formula:
    C14H13N3S

    M.W.:
    255.35

    Type:
    Small molecule

    AlogP:
    3.43

    Polar Surface Area:
    41.57

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.78

    DETAILS
  4. Tetrahydrouridine
    ALA290938

    Name:
    3-[2-(5-Methyl-1H-imidazol-4-ylmethyl)-thiazol-4-yl]-1H-indole

    Mol. Formula:
    C16H14N4S

    M.W.:
    294.38

    Type:
    Small molecule

    AlogP:
    3.91

    Polar Surface Area:
    57.36

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.60

    DETAILS
  5. Tetrahydrouridine
    ALA66918

    Name:
    1-(4-Methyl-benzyl)-2-piperazin-1-yl-1H-benzoimidazole

    Mol. Formula:
    C19H22N4

    M.W.:
    306.41

    Type:
    Small molecule

    AlogP:
    2.80

    Polar Surface Area:
    33.09

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.81

    DETAILS
  6. Tetrahydrouridine
    ALA66692

    Name:
    1-(4-Methoxy-benzyl)-2-piperazin-1-yl-1H-benzoimidazole

    Mol. Formula:
    C19H22N4O

    M.W.:
    322.41

    Type:
    Small molecule

    AlogP:
    2.50

    Polar Surface Area:
    42.32

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.80

    DETAILS
  7. Tetrahydrouridine
    ALA302743

    Name:
    1-(4-Fluoro-benzyl)-2-piperazin-1-yl-1H-benzoimidazole

    Mol. Formula:
    C18H19FN4

    M.W.:
    310.38

    Type:
    Small molecule

    AlogP:
    2.63

    Polar Surface Area:
    33.09

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.81

    DETAILS
  8. Tetrahydrouridine
    ALA68281

    Name:
    1-Allyl-2-piperazin-1-yl-1H-benzoimidazole

    Mol. Formula:
    C14H18N4

    M.W.:
    242.33

    Type:
    Small molecule

    AlogP:
    1.63

    Polar Surface Area:
    33.09

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.83

    DETAILS
  9. Tetrahydrouridine
    ALA304534

    Name:
    1-(3-Phenyl-propyl)-2-piperazin-1-yl-1H-benzoimidazole

    Mol. Formula:
    C20H24N4

    M.W.:
    320.44

    Type:
    Small molecule

    AlogP:
    3.08

    Polar Surface Area:
    33.09

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.78

    DETAILS
  10. Tetrahydrouridine
    ALA63863

    Name:
    1-Naphthalen-2-ylmethyl-2-piperazin-1-yl-1H-benzoimidazole

    Mol. Formula:
    C22H22N4

    M.W.:
    342.45

    Type:
    Small molecule

    AlogP:
    3.65

    Polar Surface Area:
    33.09

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.62

    DETAILS