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Serotonin 1d (5-HT1d) receptor

Name And Classification

ID:  ALA1983

Type:  SINGLE PROTEIN

Synonyms:   5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D | HTR1D | HTR1DA | HTRL | Serotonin 1D alpha receptor | Serotonin receptor 1D

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Membrane receptor / Family A G protein-coupled receptor / Small molecule receptor (family A GPCR) / Monoamine receptor / Serotonin receptor

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA4524122SUBSET OFSerotonin 1 (5-HT1) receptorPROTEIN FAMILY
ALA2095230SUBSET OFSerotonin 1 receptors; 5-HT1B & 5-HT1DSELECTIVITY GROUP
ALA2096904SUBSET OFSerotonin (5-HT) receptorPROTEIN FAMILY
ALA4523960SUBSET OF5-HT1D/5-HT1FSELECTIVITY GROUP

Target Components

DescriptionRelationshipAccession
5-hydroxytryptamine receptor 1DPROTEINP28221

Associated Active Ligands

  1. Tetrahydrouridine
    ALA301757

    Name:
    2-(5-tert-Butyl-1-methyl-1H-indol-3-yl)-ethylamine

    Mol. Formula:
    C15H22N2

    M.W.:
    230.35

    Type:
    Small molecule

    AlogP:
    2.98

    Polar Surface Area:
    30.95

    HBA:
    2

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    Y

    QED Weighted:
    0.84

    DETAILS
  2. Tetrahydrouridine
    ALA49826

    Name:
    5-tert-Butyl-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indole

    Mol. Formula:
    C18H26N2

    M.W.:
    270.42

    Type:
    Small molecule

    AlogP:
    4.10

    Polar Surface Area:
    19.03

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.87

    DETAILS
  3. Tetrahydrouridine
    ALA300686

    Name:
    5-Methyl-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indole

    Mol. Formula:
    C15H20N2

    M.W.:
    228.34

    Type:
    Small molecule

    AlogP:
    3.11

    Polar Surface Area:
    19.03

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.84

    DETAILS
  4. Tetrahydrouridine
    ALA44054

    Name:
    5-Isopropyl-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indole

    Mol. Formula:
    C17H24N2

    M.W.:
    256.39

    Type:
    Small molecule

    AlogP:
    3.93

    Polar Surface Area:
    19.03

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.88

    DETAILS
  5. Tetrahydrouridine
    ALA297471

    Name:
    5-tert-Butyl-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole

    Mol. Formula:
    C18H26N2

    M.W.:
    270.42

    Type:
    Small molecule

    AlogP:
    4.10

    Polar Surface Area:
    19.03

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.89

    DETAILS
  6. Tetrahydrouridine
    ALA45929

    Name:
    5-Ethyl-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indole

    Mol. Formula:
    C16H22N2

    M.W.:
    242.37

    Type:
    Small molecule

    AlogP:
    3.37

    Polar Surface Area:
    19.03

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.87

    DETAILS
  7. Tetrahydrouridine
    ALA49048

    Name:
    5-Ethyl-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole

    Mol. Formula:
    C16H22N2

    M.W.:
    242.37

    Type:
    Small molecule

    AlogP:
    3.37

    Polar Surface Area:
    19.03

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.87

    DETAILS
  8. Tetrahydrouridine
    ALA300519

    Name:
    [2-(5-Isopropyl-1H-indol-3-yl)-ethyl]-dimethyl-amine

    Mol. Formula:
    C15H22N2

    M.W.:
    230.35

    Type:
    Small molecule

    AlogP:
    3.40

    Polar Surface Area:
    19.03

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.85

    DETAILS
  9. Tetrahydrouridine
    ALA297660

    Name:
    5-Isopropyl-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole

    Mol. Formula:
    C17H24N2

    M.W.:
    256.39

    Type:
    Small molecule

    AlogP:
    3.93

    Polar Surface Area:
    19.03

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.88

    DETAILS
  10. Tetrahydrouridine
    ALA296161

    Name:
    Dimethyl-[2-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-ethyl]-amine

    Mol. Formula:
    C14H17N5

    M.W.:
    255.32

    Type:
    Small molecule

    AlogP:
    1.85

    Polar Surface Area:
    49.74

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.77

    DETAILS