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Rap guanine nucleotide exchange factor 4

Name And Classification

ID:  ALA2029198

Type:  SINGLE PROTEIN

Synonyms:   cAMP-GEFII | cAMP-regulated guanine nucleotide exchange factor II | CGEF2 | EPAC 2 | EPAC2 | Exchange factor directly activated by cAMP 2 | Exchange protein directly activated by cAMP 2 | Rap guanine nucleotide exchange factor 4 | RAPGEF4

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Unclassified protein

Target Components

DescriptionRelationshipAccession
Rap guanine nucleotide exchange factor 4PROTEINQ8WZA2

Associated Active Ligands

  1. Tetrahydrouridine
    ALA1348493

    Name:
    SID14728894

    Mol. Formula:
    C13H14F3NO3

    M.W.:
    289.25

    Type:
    Small molecule

    AlogP:
    3.08

    Polar Surface Area:
    55.40

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.93

    DETAILS
  2. Tetrahydrouridine
    ALA2030605

    Name:
    4-cyclohexyl-2-mercapto-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

    Mol. Formula:
    C11H13N3OS

    M.W.:
    235.31

    Type:
    Small molecule

    AlogP:
    1.98

    Polar Surface Area:
    69.54

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    N

    QED Weighted:
    0.58

    DETAILS
  3. Tetrahydrouridine
    ALA2030606

    Name:
    4-cyclohexyl-2-(4-methylbenzylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

    Mol. Formula:
    C19H21N3OS

    M.W.:
    339.46

    Type:
    Small molecule

    AlogP:
    4.29

    Polar Surface Area:
    69.54

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.67

    DETAILS
  4. Tetrahydrouridine
    ALA2030607

    Name:
    4-cyclohexyl-2-(3,5-dimethylbenzylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

    Mol. Formula:
    C20H23N3OS

    M.W.:
    353.49

    Type:
    Small molecule

    AlogP:
    4.60

    Polar Surface Area:
    69.54

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.64

    DETAILS
  5. Tetrahydrouridine
    ALA2030608

    Name:
    4-cyclohexyl-2-(2,4-dimethylbenzylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

    Mol. Formula:
    C20H23N3OS

    M.W.:
    353.49

    Type:
    Small molecule

    AlogP:
    4.60

    Polar Surface Area:
    69.54

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.64

    DETAILS
  6. Tetrahydrouridine
    ALA2030609

    Name:
    2-(benzylthio)-4-cyclohexyl-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

    Mol. Formula:
    C18H19N3OS

    M.W.:
    325.44

    Type:
    Small molecule

    AlogP:
    3.98

    Polar Surface Area:
    69.54

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.68

    DETAILS
  7. Tetrahydrouridine
    ALA2030610

    Name:
    4-cyclohexyl-6-oxo-2-(2,4,6-trimethylbenzylthio)-1,6-dihydropyrimidine-5-carbonitrile

    Mol. Formula:
    C21H25N3OS

    M.W.:
    367.52

    Type:
    Small molecule

    AlogP:
    4.91

    Polar Surface Area:
    69.54

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.62

    DETAILS
  8. Tetrahydrouridine
    ALA2030611

    Name:
    2-(2,5-dimethylbenzylthio)-4-isopropyl-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

    Mol. Formula:
    C17H19N3OS

    M.W.:
    313.43

    Type:
    Small molecule

    AlogP:
    3.67

    Polar Surface Area:
    69.54

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.69

    DETAILS
  9. Tetrahydrouridine
    ALA2030612

    Name:
    4-Cyclopropyl-2-(2,5-dimethylbenzylsulfanyl)-6-oxo-1,6-dihydro-pyrimidine-5-carbonitrile

    Mol. Formula:
    C17H17N3OS

    M.W.:
    311.41

    Type:
    Small molecule

    AlogP:
    3.43

    Polar Surface Area:
    69.54

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.69

    DETAILS
  10. Tetrahydrouridine
    ALA2030613

    Name:
    4-Cyclopentyl-2-(2,5-dimethyl-benzylsulfanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

    Mol. Formula:
    C19H21N3OS

    M.W.:
    339.46

    Type:
    Small molecule

    AlogP:
    4.21

    Polar Surface Area:
    69.54

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.67

    DETAILS