ID: ALA2029198
Type: SINGLE PROTEIN
Synonyms: cAMP-GEFII | cAMP-regulated guanine nucleotide exchange factor II | CGEF2 | EPAC 2 | EPAC2 | Exchange factor directly activated by cAMP 2 | Exchange protein directly activated by cAMP 2 | Rap guanine nucleotide exchange factor 4 | RAPGEF4
Organism: Homo sapiens
Species Group: Homo sapiens
Protein Target Classification: Unclassified protein
Description | Relationship | Accession |
---|---|---|
Rap guanine nucleotide exchange factor 4 | PROTEIN | Q8WZA2 |
Name:
4-cyclohexyl-2-mercapto-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
Mol. Formula:
C11H13N3OS
M.W.:
235.31
Type:
Small molecule
AlogP:
1.98
Polar Surface Area:
69.54
HBA:
4
HBD:
2
#RO5 Violations:
0
#Rotatable Bonds:
1
Passes Ro3:
N
QED Weighted:
0.58
Name:
4-cyclohexyl-2-(4-methylbenzylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
Mol. Formula:
C19H21N3OS
M.W.:
339.46
Type:
Small molecule
AlogP:
4.29
Polar Surface Area:
69.54
HBA:
4
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.67
Name:
4-cyclohexyl-2-(3,5-dimethylbenzylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
Mol. Formula:
C20H23N3OS
M.W.:
353.49
Type:
Small molecule
AlogP:
4.60
Polar Surface Area:
69.54
HBA:
4
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.64
Name:
4-cyclohexyl-2-(2,4-dimethylbenzylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
Mol. Formula:
C20H23N3OS
M.W.:
353.49
Type:
Small molecule
AlogP:
4.60
Polar Surface Area:
69.54
HBA:
4
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.64
Name:
2-(benzylthio)-4-cyclohexyl-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
Mol. Formula:
C18H19N3OS
M.W.:
325.44
Type:
Small molecule
AlogP:
3.98
Polar Surface Area:
69.54
HBA:
4
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.68
Name:
4-cyclohexyl-6-oxo-2-(2,4,6-trimethylbenzylthio)-1,6-dihydropyrimidine-5-carbonitrile
Mol. Formula:
C21H25N3OS
M.W.:
367.52
Type:
Small molecule
AlogP:
4.91
Polar Surface Area:
69.54
HBA:
4
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.62
Name:
2-(2,5-dimethylbenzylthio)-4-isopropyl-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
Mol. Formula:
C17H19N3OS
M.W.:
313.43
Type:
Small molecule
AlogP:
3.67
Polar Surface Area:
69.54
HBA:
4
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.69
Name:
4-Cyclopropyl-2-(2,5-dimethylbenzylsulfanyl)-6-oxo-1,6-dihydro-pyrimidine-5-carbonitrile
Mol. Formula:
C17H17N3OS
M.W.:
311.41
Type:
Small molecule
AlogP:
3.43
Polar Surface Area:
69.54
HBA:
4
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.69
Name:
4-Cyclopentyl-2-(2,5-dimethyl-benzylsulfanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
Mol. Formula:
C19H21N3OS
M.W.:
339.46
Type:
Small molecule
AlogP:
4.21
Polar Surface Area:
69.54
HBA:
4
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.67