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Glucocorticoid receptor

Name And Classification

ID:  ALA2034

Type:  SINGLE PROTEIN

Synonyms:   Glucocorticoid receptor | GRL | NR3C1 | Nuclear receptor subfamily 3 group C member 1

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Transcription factor / Nuclear receptor / Nuclear hormone receptor subfamily 3 / Nuclear hormone receptor subfamily 3 group C / Nuclear hormone receptor subfamily 3 group C member 1

Target Components

DescriptionRelationshipAccession
Glucocorticoid receptorPROTEINP04150

Associated Active Ligands

  1. Tetrahydrouridine
    ALA7781

    Name:
    5-Allyl-7-bromo-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-9-ol

    Mol. Formula:
    C22H21BrClNO2

    M.W.:
    446.77

    Type:
    Small molecule

    AlogP:
    7.09

    Polar Surface Area:
    41.49

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.48

    DETAILS
  2. Tetrahydrouridine
    ALA273658

    Name:
    5-Allyl-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-9-ol

    Mol. Formula:
    C22H22ClNO2

    M.W.:
    367.88

    Type:
    Small molecule

    AlogP:
    6.33

    Polar Surface Area:
    41.49

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.61

    DETAILS
  3. Tetrahydrouridine
    ALA8139

    Name:
    5-Allyl-10-allyloxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene

    Mol. Formula:
    C25H27NO2

    M.W.:
    373.50

    Type:
    Small molecule

    AlogP:
    6.54

    Polar Surface Area:
    30.49

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.60

    DETAILS
  4. Tetrahydrouridine
    ALA415309

    Name:
    5-Allyl-10-methoxy-2,2,4-trimethyl-7-vinyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene

    Mol. Formula:
    C25H27NO2

    M.W.:
    373.50

    Type:
    Small molecule

    AlogP:
    6.62

    Polar Surface Area:
    30.49

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.61

    DETAILS
  5. Tetrahydrouridine
    ALA267231

    Name:
    5-Allyl-10-difluoromethoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene

    Mol. Formula:
    C23H23F2NO2

    M.W.:
    383.44

    Type:
    Small molecule

    AlogP:
    6.57

    Polar Surface Area:
    30.49

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.61

    DETAILS
  6. Tetrahydrouridine
    ALA8007

    Name:
    5-Allyl-10-chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene

    Mol. Formula:
    C22H22ClNO

    M.W.:
    351.88

    Type:
    Small molecule

    AlogP:
    6.62

    Polar Surface Area:
    21.26

    HBA:
    2

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.61

    DETAILS
  7. Tetrahydrouridine
    ALA8026

    Name:
    5-Allyl-10-ethoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene

    Mol. Formula:
    C24H27NO2

    M.W.:
    361.49

    Type:
    Small molecule

    AlogP:
    6.37

    Polar Surface Area:
    30.49

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.64

    DETAILS
  8. Tetrahydrouridine
    ALA7987

    Name:
    5-Allyl-9-chloro-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene

    Mol. Formula:
    C23H24ClNO2

    M.W.:
    381.90

    Type:
    Small molecule

    AlogP:
    6.63

    Polar Surface Area:
    30.49

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.60

    DETAILS
  9. Tetrahydrouridine
    ALA7988

    Name:
    5-Allyl-9-fluoro-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene

    Mol. Formula:
    C23H24FNO2

    M.W.:
    365.45

    Type:
    Small molecule

    AlogP:
    6.12

    Polar Surface Area:
    30.49

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.66

    DETAILS
  10. Tetrahydrouridine
    ALA266282

    Name:
    5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene

    Mol. Formula:
    C23H25NO2

    M.W.:
    347.46

    Type:
    Small molecule

    AlogP:
    5.98

    Polar Surface Area:
    30.49

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.69

    DETAILS