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Menin/Histone-lysine N-methyltransferase MLL

Name And Classification

ID:  ALA2093861

Type:  PROTEIN-PROTEIN INTERACTION

Synonyms:   MEN1 | Menin | SCG2

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Unclassified protein

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA1293299SUPERSET OFHistone-lysine N-methyltransferase MLLSINGLE PROTEIN
ALA1615381SUPERSET OFMeninSINGLE PROTEIN
ALA3883320OVERLAPS WITHHistone-lysine N-methyltransferase 2A/WDR5PROTEIN-PROTEIN INTERACTION
ALA3137282OVERLAPS WITHMLL1/ASH2L/RBBP5/WDR5 complexPROTEIN COMPLEX
ALA4106124OVERLAPS WITHMLL1-ASH2L/RbBP5/WDR5/DPY30PROTEIN-PROTEIN INTERACTION

Target Components

DescriptionRelationshipAccession
MeninPROTEINO00255
Histone-lysine N-methyltransferase 2APROTEINQ03164

Associated Active Ligands

  1. Tetrahydrouridine
    ALA6608

    Name:
    SID26756925

    Mol. Formula:
    C27H29NO11

    M.W.:
    543.53

    Type:
    Small molecule

    AlogP:
    0.00

    Polar Surface Area:
    206.07

    HBA:
    12

    HBD:
    6

    #RO5 Violations:
    3

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.24

    DETAILS
  2. Tetrahydrouridine
    ALA268601

    Name:
    SID50104770

    Mol. Formula:
    C29H32O13

    M.W.:
    588.56

    Type:
    Small molecule

    AlogP:
    1.34

    Polar Surface Area:
    160.83

    HBA:
    13

    HBD:
    3

    #RO5 Violations:
    2

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.43

    DETAILS
  3. Tetrahydrouridine
    ALA10206

    Name:
    SID50112971

    Mol. Formula:
    C22H20N2O5

    M.W.:
    392.41

    Type:
    Small molecule

    AlogP:
    2.35

    Polar Surface Area:
    101.65

    HBA:
    7

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.51

    DETAILS
  4. Tetrahydrouridine
    ALA274619

    Name:
    SID26747419

    Mol. Formula:
    C19H20N8O5

    M.W.:
    440.42

    Type:
    Small molecule

    AlogP:
    0.24

    Polar Surface Area:
    219.33

    HBA:
    10

    HBD:
    6

    #RO5 Violations:
    1

    #Rotatable Bonds:
    9

    Passes Ro3:
    N

    QED Weighted:
    0.26

    DETAILS
  5. Tetrahydrouridine
    ALA279731

    Name:
    SID11113988

    Mol. Formula:
    C7H14NO5P

    M.W.:
    223.16

    Type:
    Small molecule

    AlogP:
    -0.38

    Polar Surface Area:
    106.86

    HBA:
    3

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.49

    DETAILS
  6. Tetrahydrouridine
    ALA24223

    Name:
    SID26749011

    Mol. Formula:
    C24H34N2O5

    M.W.:
    430.55

    Type:
    Small molecule

    AlogP:
    2.77

    Polar Surface Area:
    95.94

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    9

    Passes Ro3:
    N

    QED Weighted:
    0.59

    DETAILS
  7. Tetrahydrouridine
    ALA34668

    Name:
    SID50112891

    Mol. Formula:
    C16H16NO6P

    M.W.:
    349.28

    Type:
    Small molecule

    AlogP:
    2.31

    Polar Surface Area:
    120.00

    HBA:
    4

    HBD:
    4

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.50

    DETAILS
  8. Tetrahydrouridine
    ALA36622

    Name:
    SID11111041

    Mol. Formula:
    C19H23NO5

    M.W.:
    345.40

    Type:
    Small molecule

    AlogP:
    2.51

    Polar Surface Area:
    58.18

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.74

    DETAILS
  9. Tetrahydrouridine
    ALA156

    Name:
    SID11110764

    Mol. Formula:
    C20H22N8O5

    M.W.:
    454.45

    Type:
    Small molecule

    AlogP:
    0.27

    Polar Surface Area:
    210.54

    HBA:
    10

    HBD:
    5

    #RO5 Violations:
    0

    #Rotatable Bonds:
    9

    Passes Ro3:
    N

    QED Weighted:
    0.29

    DETAILS
  10. Tetrahydrouridine
    ALA860

    Name:
    SID11111071

    Mol. Formula:
    C19H21NO

    M.W.:
    279.38

    Type:
    Small molecule

    AlogP:
    3.96

    Polar Surface Area:
    12.47

    HBA:
    2

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.84

    DETAILS