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Adrenergic receptor alpha-2

Name And Classification

ID:  ALA2093864

Type:  PROTEIN FAMILY

Synonyms:   Adra2c | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenergic receptor | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | Alpha-2CAR

Organism:  Rattus norvegicus

Species Group:  Rattus norvegicus

Protein Target Classification:   Membrane receptor / Family A G protein-coupled receptor / Small molecule receptor (family A GPCR) / Monoamine receptor / Adrenergic receptor

Target Relations

ALA IDRelationshipPref NameTarget Type

Target Components

DescriptionRelationshipAccession
Alpha-2C adrenergic receptorPROTEINP22086
Alpha-2B adrenergic receptorPROTEINP19328
Alpha-2A adrenergic receptorPROTEINP22909

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Active Ligands

  1. Tetrahydrouridine
    ALA9763

    Name:
    2-(2-Allyloxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole

    Mol. Formula:
    C14H16N2O3

    M.W.:
    260.29

    Type:
    Small molecule

    AlogP:
    1.36

    Polar Surface Area:
    52.08

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.83

    DETAILS
  2. Tetrahydrouridine
    ALA417789

    Name:
    2-(2-Cyclopentyloxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole

    Mol. Formula:
    C16H20N2O3

    M.W.:
    288.35

    Type:
    Small molecule

    AlogP:
    2.12

    Polar Surface Area:
    52.08

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.93

    DETAILS
  3. Tetrahydrouridine
    ALA9775

    Name:
    2-(2-Ethyl-2,3-dihydro-benzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole: 1/8M H2O

    Mol. Formula:
    C13H16N2O2

    M.W.:
    232.28

    Type:
    Small molecule

    AlogP:
    1.61

    Polar Surface Area:
    42.85

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.84

    DETAILS
  4. Tetrahydrouridine
    ALA9612

    Name:
    (2-Benzo[1,3]dioxol-5-yl-ethyl)-[(3aR,6R)-1-(2,3,3a,4,5,6-hexahydro-benzo[de]chromen-6-yl)methyl]-methyl-amine

    Mol. Formula:
    C23H27NO3

    M.W.:
    365.47

    Type:
    Small molecule

    AlogP:
    4.33

    Polar Surface Area:
    30.93

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.79

    DETAILS
  5. Tetrahydrouridine
    ALA10115

    Name:
    6-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-3H-benzooxazol-2-one

    Mol. Formula:
    C22H26N2O3

    M.W.:
    366.46

    Type:
    Small molecule

    AlogP:
    4.14

    Polar Surface Area:
    58.73

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.71

    DETAILS
  6. Tetrahydrouridine
    ALA274391

    Name:
    [2-(2,3-Dihydro-benzofuran-6-yl)-ethyl]-((R)-5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amine

    Mol. Formula:
    C23H29NO2

    M.W.:
    351.49

    Type:
    Small molecule

    AlogP:
    4.22

    Polar Surface Area:
    21.70

    HBA:
    3

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.78

    DETAILS
  7. Tetrahydrouridine
    ALA9810

    Name:
    (2-Benzo[1,3]dioxol-5-yl-ethyl)-((R)-5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-prop-2-ynyl-amine

    Mol. Formula:
    C24H27NO3

    M.W.:
    377.48

    Type:
    Small molecule

    AlogP:
    4.02

    Polar Surface Area:
    30.93

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.68

    DETAILS
  8. Tetrahydrouridine
    ALA269208

    Name:
    (2-Benzo[1,3]dioxol-5-yl-ethyl)-cyclopropylmethyl-((R)-5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-amine

    Mol. Formula:
    C25H31NO3

    M.W.:
    393.53

    Type:
    Small molecule

    AlogP:
    4.80

    Polar Surface Area:
    30.93

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.64

    DETAILS
  9. Tetrahydrouridine
    ALA10338

    Name:
    2-(2-Isopropyl-2,3-dihydro-benzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole

    Mol. Formula:
    C14H18N2O2

    M.W.:
    246.31

    Type:
    Small molecule

    AlogP:
    1.85

    Polar Surface Area:
    42.85

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.87

    DETAILS
  10. Tetrahydrouridine
    ALA276667

    Name:
    (2-Benzo[1,3]dioxol-5-yl-ethyl)-methyl-(6,7,8,9-tetrahydro-naphtho[1,2-d][1,3]dioxol-6-ylmethyl)-amine

    Mol. Formula:
    C22H25NO4

    M.W.:
    367.45

    Type:
    Small molecule

    AlogP:
    3.74

    Polar Surface Area:
    40.16

    HBA:
    5

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.81

    DETAILS