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Serotonin 3 (5-HT3) receptor

Name And Classification

ID:  ALA2094116

Type:  PROTEIN COMPLEX

Synonyms:   5-HT-3 | 5-HT3-A | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 | 5-hydroxytryptamine receptor 3A | 5ht3 | Htr3 | Htr3a | Serotonin receptor 3A | Serotonin-gated ion channel receptor

Organism:  Rattus norvegicus

Species Group:  Rattus norvegicus

Protein Target Classification:   Ion channel / Ligand-gated ion channel / 5HT3 receptor

Target Relations

ALA IDRelationshipPref NameTarget Type

Target Components

DescriptionRelationshipAccession
5-hydroxytryptamine receptor 3APROTEINP35563
5-hydroxytryptamine receptor 3BPROTEINQ9JJ16

Associated Active Ligands

  1. Tetrahydrouridine
    ALA39

    Name:
    3-(2-Amino-ethyl)-1H-indol-5-ol

    Mol. Formula:
    C10H12N2O

    M.W.:
    176.22

    Type:
    Small molecule

    AlogP:
    1.37

    Polar Surface Area:
    62.04

    HBA:
    2

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.65

    DETAILS
  2. Tetrahydrouridine
    ALA7818

    Name:
    2'-(5-methoxy-1-methyl-1H-indol-3-yl)-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazole]

    Mol. Formula:
    C19H23N3O2

    M.W.:
    325.41

    Type:
    Small molecule

    AlogP:
    2.43

    Polar Surface Area:
    38.99

    HBA:
    5

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.85

    DETAILS
  3. Tetrahydrouridine
    ALA267076

    Name:
    1-methyl-3-(4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-yl)-1H-indol-5-amine

    Mol. Formula:
    C18H22N4O

    M.W.:
    310.40

    Type:
    Small molecule

    AlogP:
    2.00

    Polar Surface Area:
    55.78

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    N

    QED Weighted:
    0.82

    DETAILS
  4. Tetrahydrouridine
    ALA8279

    Name:
    2'-(1-methyl-5-nitro-1H-indol-3-yl)-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazole]

    Mol. Formula:
    C18H20N4O3

    M.W.:
    340.38

    Type:
    Small molecule

    AlogP:
    2.33

    Polar Surface Area:
    72.90

    HBA:
    6

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.62

    DETAILS
  5. Tetrahydrouridine
    ALA267297

    Name:
    2'-(1,5-dimethyl-1H-indol-3-yl)-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazole]

    Mol. Formula:
    C19H23N3O

    M.W.:
    309.41

    Type:
    Small molecule

    AlogP:
    2.73

    Polar Surface Area:
    29.76

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    N

    QED Weighted:
    0.81

    DETAILS
  6. Tetrahydrouridine
    ALA267991

    Name:
    8-Methyl-2-(1-methyl-1H-indol-3-yl)-1-oxa-3,8-diaza-spiro[4.5]dec-2-ene

    Mol. Formula:
    C17H21N3O

    M.W.:
    283.37

    Type:
    Small molecule

    AlogP:
    2.42

    Polar Surface Area:
    29.76

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    N

    QED Weighted:
    0.80

    DETAILS
  7. Tetrahydrouridine
    ALA8261

    Name:
    1-methyl-3-(4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-yl)-1H-indol-5-ol

    Mol. Formula:
    C18H21N3O2

    M.W.:
    311.38

    Type:
    Small molecule

    AlogP:
    2.13

    Polar Surface Area:
    49.99

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    N

    QED Weighted:
    0.88

    DETAILS
  8. Tetrahydrouridine
    ALA268892

    Name:
    2'-(5-fluoro-1-methyl-1H-indol-3-yl)-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazole]

    Mol. Formula:
    C18H20FN3O

    M.W.:
    313.38

    Type:
    Small molecule

    AlogP:
    2.56

    Polar Surface Area:
    29.76

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    N

    QED Weighted:
    0.81

    DETAILS
  9. Tetrahydrouridine
    ALA7857

    Name:
    2'-(3-methoxyphenyl)-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazole]

    Mol. Formula:
    C16H20N2O2

    M.W.:
    272.35

    Type:
    Small molecule

    AlogP:
    1.94

    Polar Surface Area:
    34.06

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.82

    DETAILS
  10. Tetrahydrouridine
    ALA274378

    Name:
    2'-(1-benzothien-3-yl)-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazole]

    Mol. Formula:
    C17H18N2OS

    M.W.:
    298.41

    Type:
    Small molecule

    AlogP:
    3.14

    Polar Surface Area:
    24.83

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    N

    QED Weighted:
    0.81

    DETAILS