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Melatonin receptor

Name And Classification

ID:  ALA2094268

Type:  PROTEIN FAMILY

Synonyms:   Mel-1A-R | Mel1a receptor | Melatonin receptor type 1A | MTNR1A

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Membrane receptor / Family A G protein-coupled receptor / Small molecule receptor (family A GPCR) / Monoamine-derivative receptor (family A GPCR) / Melatonin receptor

Target Relations

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ALA IDRelationshipPref NameTarget Type

Target Components

DescriptionRelationshipAccession
Melatonin receptor type 1APROTEINP48039
Melatonin receptor type 1BPROTEINP49286

Associated Recombinant Proteins

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NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Antibodies

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NameSpecificationsSpecies reactivityspeciesApplicationView Details

Associated Active Ligands

  1. Tetrahydrouridine
    ALA11356

    Name:
    N-[2-(3H-Benzo[f]chromen-10-yl)-ethyl]-acetamide

    Mol. Formula:
    C17H17NO2

    M.W.:
    267.33

    Type:
    Small molecule

    AlogP:
    2.92

    Polar Surface Area:
    38.33

    HBA:
    2

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    Y

    QED Weighted:
    0.93

    DETAILS
  2. Tetrahydrouridine
    ALA11404

    Name:
    N-(2-Naphtho[2,1-b]furan-9-yl-ethyl)-acetamide

    Mol. Formula:
    C16H15NO2

    M.W.:
    253.30

    Type:
    Small molecule

    AlogP:
    3.26

    Polar Surface Area:
    42.24

    HBA:
    2

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.78

    DETAILS
  3. Tetrahydrouridine
    ALA11416

    Name:
    N-[2-(1-Oxo-1,2-dihydro-naphtho[2,1-b]furan-9-yl)-ethyl]-acetamide

    Mol. Formula:
    C16H15NO3

    M.W.:
    269.30

    Type:
    Small molecule

    AlogP:
    2.09

    Polar Surface Area:
    55.40

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    Y

    QED Weighted:
    0.93

    DETAILS
  4. Tetrahydrouridine
    ALA10816

    Name:
    N-[2-(1-Hydroxy-1,2-dihydro-naphtho[2,1-b]furan-9-yl)-ethyl]-acetamide

    Mol. Formula:
    C16H17NO3

    M.W.:
    271.32

    Type:
    Small molecule

    AlogP:
    1.94

    Polar Surface Area:
    58.56

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    Y

    QED Weighted:
    0.90

    DETAILS
  5. Tetrahydrouridine
    ALA273294

    Name:
    N-[2-(2-Methyl-1,2-dihydro-naphtho[2,1-b]furan-9-yl)-ethyl]-acetamide

    Mol. Formula:
    C17H19NO2

    M.W.:
    269.34

    Type:
    Small molecule

    AlogP:
    2.84

    Polar Surface Area:
    38.33

    HBA:
    2

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    Y

    QED Weighted:
    0.93

    DETAILS
  6. Tetrahydrouridine
    ALA274358

    Name:
    N-[2-(2,3-Dihydro-1H-benzo[f]chromen-10-yl)-ethyl]-acetamide

    Mol. Formula:
    C17H19NO2

    M.W.:
    269.34

    Type:
    Small molecule

    AlogP:
    2.84

    Polar Surface Area:
    38.33

    HBA:
    2

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    Y

    QED Weighted:
    0.93

    DETAILS
  7. Tetrahydrouridine
    ALA11148

    Name:
    N-[2-(2,3,6,7,8,9-Hexahydro-naphtho[2,3-b][1,4]dioxin-6-yl)-ethyl]-acetamide

    Mol. Formula:
    C16H21NO3

    M.W.:
    275.35

    Type:
    Small molecule

    AlogP:
    2.40

    Polar Surface Area:
    47.56

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    Y

    QED Weighted:
    0.92

    DETAILS
  8. Tetrahydrouridine
    ALA11328

    Name:
    N-[2-(2,3,7,8,9,10-Hexahydro-1H-benzo[f]chromen-10-yl)-ethyl]-acetamide

    Mol. Formula:
    C17H23NO2

    M.W.:
    273.38

    Type:
    Small molecule

    AlogP:
    2.96

    Polar Surface Area:
    38.33

    HBA:
    2

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    Y

    QED Weighted:
    0.92

    DETAILS
  9. Tetrahydrouridine
    ALA15060

    Name:
    N-[2-(5-Methoxy-2-phenyl-1H-indol-3-yl)-ethyl]-acetamide

    Mol. Formula:
    C19H20N2O2

    M.W.:
    308.38

    Type:
    Small molecule

    AlogP:
    3.52

    Polar Surface Area:
    54.12

    HBA:
    2

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.76

    DETAILS
  10. Tetrahydrouridine
    ALA14975

    Name:
    Cyclopropanecarboxylic acid [2-(5-methoxy-2-phenyl-1H-indol-3-yl)-ethyl]-amide

    Mol. Formula:
    C21H22N2O2

    M.W.:
    334.42

    Type:
    Small molecule

    AlogP:
    3.91

    Polar Surface Area:
    54.12

    HBA:
    2

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.72

    DETAILS