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Dopamine D2 receptor

Name And Classification

ID:  ALA217

Type:  SINGLE PROTEIN

Synonyms:   D(2) dopamine receptor | Dopamine D2 receptor | DRD2

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Membrane receptor / Family A G protein-coupled receptor / Small molecule receptor (family A GPCR) / Monoamine receptor / Dopamine receptor

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA3038478SUBSET OFDopamine receptor D2L/neurotensin receptor NTS1PROTEIN COMPLEX
ALA2111341SUBSET OFDopamine D1 and D2 receptorSELECTIVITY GROUP
ALA2095169SUBSET OFDopamine receptors; D2 & D3SELECTIVITY GROUP
ALA2111468SUBSET OFDopamine D2 receptor and serotonin 2a receptorSELECTIVITY GROUP
ALA2331075SUBSET OFD2-like dopamine receptorPROTEIN FAMILY
ALA4296096SUBSET OFD(2) dopamine receptor/Metabotropic glutamate receptor 5PROTEIN COMPLEX
ALA2095396SUBSET OFDopamine receptors; D2 & D4SELECTIVITY GROUP
ALA2111460SUBSET OFDopamine D2 receptor and serotonin 1a receptorSELECTIVITY GROUP
ALA2096905SUBSET OFDopamine receptorPROTEIN FAMILY

Target Components

DescriptionRelationshipAccession
D(2) dopamine receptorPROTEINP14416

Associated Antibodies

NameSpecificationsSpecies reactivityspeciesApplicationView Details
ASG-5ME (anti-SLC44A4)Human,MouseHuman
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Expand

Associated Active Ligands

  1. Tetrahydrouridine
    ALA267014

    Name:
    3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-pyrrolo[2,3-b]pyridine

    Mol. Formula:
    C18H19ClN4

    M.W.:
    326.83

    Type:
    Small molecule

    AlogP:
    3.54

    Polar Surface Area:
    35.16

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.80

    DETAILS
  2. Tetrahydrouridine
    ALA493

    Name:
    5-Bromo-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid (10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxo-octahydro-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-amide

    Mol. Formula:
    C32H40BrN5O5

    M.W.:
    654.61

    Type:
    Small molecule

    AlogP:
    3.19

    Polar Surface Area:
    118.21

    HBA:
    6

    HBD:
    3

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.46

    DETAILS
  3. Tetrahydrouridine
    ALA11845

    Name:
    6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene-1,2-diol

    Mol. Formula:
    C16H25NO2

    M.W.:
    263.38

    Type:
    Small molecule

    AlogP:
    3.08

    Polar Surface Area:
    43.70

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.80

    DETAILS
  4. Tetrahydrouridine
    ALA531

    Name:
    9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline

    Mol. Formula:
    C19H26N2S

    M.W.:
    314.50

    Type:
    Small molecule

    AlogP:
    4.27

    Polar Surface Area:
    19.03

    HBA:
    2

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.91

    DETAILS
  5. Tetrahydrouridine
    ALA15270

    Name:
    (1-Benzyl-piperidin-4-yl)-[6-chloro-5-(4-chloro-phenylsulfanyl)-2-methyl-pyrimidin-4-yl]-amine

    Mol. Formula:
    C23H24Cl2N4S

    M.W.:
    459.45

    Type:
    Small molecule

    AlogP:
    6.32

    Polar Surface Area:
    41.05

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.44

    DETAILS
  6. Tetrahydrouridine
    ALA274047

    Name:
    (1S,2R,6S,7R)-4-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-4-aza-tricyclo[5.2.1.0*2,6*]decane-3,5-dione

    Mol. Formula:
    C21H29N5O2

    M.W.:
    383.50

    Type:
    Small molecule

    AlogP:
    1.41

    Polar Surface Area:
    69.64

    HBA:
    6

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.55

    DETAILS
  7. Tetrahydrouridine
    ALA407641

    Name:
    [4-Chloro-6-(4-methyl-piperazin-1-yl)-5-methylsulfanyl-pyrimidin-2-yl]-methyl-amine

    Mol. Formula:
    C11H18ClN5S

    M.W.:
    287.82

    Type:
    Small molecule

    AlogP:
    1.65

    Polar Surface Area:
    44.29

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.67

    DETAILS
  8. Tetrahydrouridine
    ALA15242

    Name:
    4-Chloro-2-(4-methyl-piperazin-1-yl)-3-phenylsulfanyl-quinoline

    Mol. Formula:
    C20H20ClN3S

    M.W.:
    369.92

    Type:
    Small molecule

    AlogP:
    4.79

    Polar Surface Area:
    19.37

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.66

    DETAILS
  9. Tetrahydrouridine
    ALA14899

    Name:
    [4-Chloro-6-(4-methyl-piperazin-1-yl)-5-phenylsulfanyl-pyrimidin-2-yl]-methyl-amine

    Mol. Formula:
    C16H20ClN5S

    M.W.:
    349.89

    Type:
    Small molecule

    AlogP:
    3.07

    Polar Surface Area:
    44.29

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.86

    DETAILS
  10. Tetrahydrouridine
    ALA14998

    Name:
    4-Chloro-5-(4-chloro-phenylsulfanyl)-2-methyl-6-(4-methyl-piperazin-1-yl)-pyrimidine

    Mol. Formula:
    C16H18Cl2N4S

    M.W.:
    369.32

    Type:
    Small molecule

    AlogP:
    3.99

    Polar Surface Area:
    32.26

    HBA:
    5

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.76

    DETAILS