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Cannabinoid CB1 receptor

Name And Classification

ID:  ALA218

Type:  SINGLE PROTEIN

Synonyms:   CANN6 | Cannabinoid receptor 1 | CB-R | CB1 | CNR | CNR1

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Membrane receptor / Family A G protein-coupled receptor / Small molecule receptor (family A GPCR) / Lipid-like ligand receptor (family A GPCR) / Cannabinoid receptor

Target Relations

ALA IDRelationshipPref NameTarget Type

Target Components

DescriptionRelationshipAccession
Cannabinoid receptor 1PROTEINP21554

Associated Active Ligands

  1. Tetrahydrouridine
    ALA111

    Name:
    5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide

    Mol. Formula:
    C22H21Cl3N4O

    M.W.:
    463.80

    Type:
    Small molecule

    AlogP:
    5.94

    Polar Surface Area:
    50.16

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.52

    DETAILS
  2. Tetrahydrouridine
    ALA416718

    Name:
    1-(4-Chloro-phenyl)-5-cyano-2-(2,4-dichloro-phenyl)-1H-imidazole-4-carboxylic acid (hexahydro-cyclopenta[c]pyrrol-2-yl)-amide

    Mol. Formula:
    C24H20Cl3N5O

    M.W.:
    500.82

    Type:
    Small molecule

    AlogP:
    5.75

    Polar Surface Area:
    73.95

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    2

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.50

    DETAILS
  3. Tetrahydrouridine
    ALA15966

    Name:
    5-Bromo-1-(4-chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazole-4-carboxylic acid (hexahydro-cyclopenta[c]pyrrol-2-yl)-amide

    Mol. Formula:
    C23H20BrCl3N4O

    M.W.:
    554.70

    Type:
    Small molecule

    AlogP:
    6.64

    Polar Surface Area:
    50.16

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    2

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.39

    DETAILS
  4. Tetrahydrouridine
    ALA15764

    Name:
    5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid (1,2-dimethyl-propyl)-amide

    Mol. Formula:
    C22H22Cl3N3O

    M.W.:
    450.80

    Type:
    Small molecule

    AlogP:
    6.58

    Polar Surface Area:
    46.92

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.48

    DETAILS
  5. Tetrahydrouridine
    ALA15635

    Name:
    1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-1H-imidazole-4-carboxylic acid azepan-1-ylamide

    Mol. Formula:
    C22H21Cl3N4O

    M.W.:
    463.80

    Type:
    Small molecule

    AlogP:
    6.02

    Polar Surface Area:
    50.16

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.51

    DETAILS
  6. Tetrahydrouridine
    ALA278236

    Name:
    1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-5-methyl-1H-imidazole-4-carboxylic acid [2-(4-chloro-phenyl)-ethyl]-amide

    Mol. Formula:
    C25H19Cl4N3O

    M.W.:
    519.26

    Type:
    Small molecule

    AlogP:
    7.43

    Polar Surface Area:
    46.92

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    2

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.29

    DETAILS
  7. Tetrahydrouridine
    ALA15918

    Name:
    1-(4-Chloro-phenyl)-5-(2,4-dichloro-phenyl)-1H-[1,2,4]triazole-3-carboxylic acid (2-dimethylamino-ethyl)-amide

    Mol. Formula:
    C19H18Cl3N5O

    M.W.:
    438.75

    Type:
    Small molecule

    AlogP:
    4.19

    Polar Surface Area:
    63.05

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.63

    DETAILS
  8. Tetrahydrouridine
    ALA279787

    Name:
    1-(4-Chloro-phenyl)-5-(2,4-dichloro-phenyl)-1H-[1,2,4]triazole-3-carboxylic acid indan-1-ylamide

    Mol. Formula:
    C24H17Cl3N4O

    M.W.:
    483.79

    Type:
    Small molecule

    AlogP:
    6.31

    Polar Surface Area:
    59.81

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.37

    DETAILS
  9. Tetrahydrouridine
    ALA15772

    Name:
    1-(4-Chloro-phenyl)-5-(2,4-dichloro-phenyl)-1H-[1,2,4]triazole-3-carboxylic acid (4-methyl-cyclohexyl)-amide

    Mol. Formula:
    C22H21Cl3N4O

    M.W.:
    463.80

    Type:
    Small molecule

    AlogP:
    6.20

    Polar Surface Area:
    59.81

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.50

    DETAILS
  10. Tetrahydrouridine
    ALA418544

    Name:
    1-(4-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-5-ethynyl-1H-imidazole-4-carboxylic acid (hexahydro-cyclopenta[c]pyrrol-2-yl)-amide

    Mol. Formula:
    C25H21Cl3N4O

    M.W.:
    499.83

    Type:
    Small molecule

    AlogP:
    5.86

    Polar Surface Area:
    50.16

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.46

    DETAILS