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Dopamine D4 receptor

Name And Classification

ID:  ALA219

Type:  SINGLE PROTEIN

Synonyms:   D(2C) dopamine receptor | D(4) dopamine receptor | Dopamine D4 receptor | DRD4

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Membrane receptor / Family A G protein-coupled receptor / Small molecule receptor (family A GPCR) / Monoamine receptor / Dopamine receptor

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA2331075SUBSET OFD2-like dopamine receptorPROTEIN FAMILY
ALA2095396SUBSET OFDopamine receptors; D2 & D4SELECTIVITY GROUP
ALA2096905SUBSET OFDopamine receptorPROTEIN FAMILY
ALA2097165SUBSET OFDopamine receptors; D3 & D4SELECTIVITY GROUP

Target Components

DescriptionRelationshipAccession
D(4) dopamine receptorPROTEINP21917

Associated Active Ligands

  1. Tetrahydrouridine
    ALA268558

    Name:
    1-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrazolo[5,1-a]isoquinoline

    Mol. Formula:
    C22H21ClN4

    M.W.:
    376.89

    Type:
    Small molecule

    AlogP:
    4.46

    Polar Surface Area:
    23.78

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.53

    DETAILS
  2. Tetrahydrouridine
    ALA269576

    Name:
    3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrazolo[1,5-a]quinoline

    Mol. Formula:
    C22H21ClN4

    M.W.:
    376.89

    Type:
    Small molecule

    AlogP:
    4.46

    Polar Surface Area:
    23.78

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.53

    DETAILS
  3. Tetrahydrouridine
    ALA7505

    Name:
    3-(4-Methyl-piperazin-1-ylmethyl)-pyrazolo[1,5-a]pyridine

    Mol. Formula:
    C13H18N4

    M.W.:
    230.31

    Type:
    Small molecule

    AlogP:
    1.08

    Polar Surface Area:
    23.78

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.77

    DETAILS
  4. Tetrahydrouridine
    ALA269202

    Name:
    3-[4-(3-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrazolo[1,5-a]pyridine

    Mol. Formula:
    C18H19ClN4

    M.W.:
    326.83

    Type:
    Small molecule

    AlogP:
    3.31

    Polar Surface Area:
    23.78

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.74

    DETAILS
  5. Tetrahydrouridine
    ALA273860

    Name:
    3-(4-Phenyl-piperazin-1-ylmethyl)-pyrazolo[1,5-a]pyridine

    Mol. Formula:
    C18H20N4

    M.W.:
    292.39

    Type:
    Small molecule

    AlogP:
    2.66

    Polar Surface Area:
    23.78

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.74

    DETAILS
  6. Tetrahydrouridine
    ALA7508

    Name:
    3-[4-(4-Iodo-phenyl)-piperazin-1-ylmethyl]-pyrazolo[1,5-a]pyridine

    Mol. Formula:
    C18H19IN4

    M.W.:
    418.28

    Type:
    Small molecule

    AlogP:
    3.26

    Polar Surface Area:
    23.78

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.61

    DETAILS
  7. Tetrahydrouridine
    ALA268190

    Name:
    3-(4-Cyclohexyl-piperazin-1-ylmethyl)-pyrazolo[1,5-a]pyridine

    Mol. Formula:
    C18H26N4

    M.W.:
    298.43

    Type:
    Small molecule

    AlogP:
    2.78

    Polar Surface Area:
    23.78

    HBA:
    4

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.87

    DETAILS
  8. Tetrahydrouridine
    ALA21252

    Name:
    N-{4-[4-(4-Chloro-phenyl)-piperazin-1-yl]-butyl}-acetamide

    Mol. Formula:
    C16H24ClN3O

    M.W.:
    309.84

    Type:
    Small molecule

    AlogP:
    2.38

    Polar Surface Area:
    35.58

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.82

    DETAILS
  9. Tetrahydrouridine
    ALA278288

    Name:
    N-{5-[4-(4-Chloro-phenyl)-piperazin-1-yl]-pentyl}-2,2-dimethyl-propionamide

    Mol. Formula:
    C20H32ClN3O

    M.W.:
    365.95

    Type:
    Small molecule

    AlogP:
    3.79

    Polar Surface Area:
    35.58

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.75

    DETAILS
  10. Tetrahydrouridine
    ALA423287

    Name:
    N-{3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-propyl}-2,2-dimethyl-propionamide

    Mol. Formula:
    C18H28ClN3O

    M.W.:
    337.90

    Type:
    Small molecule

    AlogP:
    3.01

    Polar Surface Area:
    35.58

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.84

    DETAILS