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MAP kinase-activated protein kinase 2

Name And Classification

ID:  ALA2208

Type:  SINGLE PROTEIN

Synonyms:   2.7.11.1 | MAP kinase-activated protein kinase 2 | MAPK-activated protein kinase 2 | MAPKAP kinase 2 | MAPKAP-K2 | MAPKAPK-2 | MAPKAPK2 | MK-2 | MK2

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Kinase / Protein Kinase / CAMK protein kinase group / CAMK protein kinase MAPKAPK family / CAMK protein kinase MAPKAPK subfamily

Target Components

DescriptionRelationshipAccession
MAP kinase-activated protein kinase 2PROTEINP49137

Associated Active Ligands

  1. Tetrahydrouridine
    ALA178952

    Name:
    2,4-Diamino-5H-thiochromeno[2,3-b]pyridine-3-carbonitrile

    Mol. Formula:
    C13H10N4S

    M.W.:
    254.32

    Type:
    Small molecule

    AlogP:
    2.17

    Polar Surface Area:
    88.72

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    0

    Passes Ro3:
    N

    QED Weighted:
    0.64

    DETAILS
  2. Tetrahydrouridine
    ALA180574

    Name:
    2,4-Diamino-10,10-dioxo-5,10-dihydro-10lambda*6*-thiochromeno[2,3-b]pyridine-3-carbonitrile

    Mol. Formula:
    C13H10N4O2S

    M.W.:
    286.32

    Type:
    Small molecule

    AlogP:
    0.85

    Polar Surface Area:
    122.86

    HBA:
    6

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    0

    Passes Ro3:
    N

    QED Weighted:
    0.63

    DETAILS
  3. Tetrahydrouridine
    ALA360278

    Name:
    2,4-Diamino-10-methyl-5,10-dihydro-benzo[b][1,8]naphthyridine-3-carbonitrile

    Mol. Formula:
    C14H13N5

    M.W.:
    251.29

    Type:
    Small molecule

    AlogP:
    1.79

    Polar Surface Area:
    91.96

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    0

    Passes Ro3:
    N

    QED Weighted:
    0.74

    DETAILS
  4. Tetrahydrouridine
    ALA225519

    Name:
    2-pyridin-4-yl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

    Mol. Formula:
    C12H11N3O

    M.W.:
    213.24

    Type:
    Small molecule

    AlogP:
    1.36

    Polar Surface Area:
    57.78

    HBA:
    2

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    Y

    QED Weighted:
    0.75

    DETAILS
  5. Tetrahydrouridine
    ALA226232

    Name:
    2-(2-chloropyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one

    Mol. Formula:
    C12H10ClN3O

    M.W.:
    247.69

    Type:
    Small molecule

    AlogP:
    2.02

    Polar Surface Area:
    57.78

    HBA:
    2

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    1

    Passes Ro3:
    Y

    QED Weighted:
    0.76

    DETAILS
  6. Tetrahydrouridine
    ALA388566

    Name:
    2-(2-phenylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-

    Mol. Formula:
    C18H15N3O

    M.W.:
    289.34

    Type:
    Small molecule

    AlogP:
    3.03

    Polar Surface Area:
    57.78

    HBA:
    2

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.76

    DETAILS
  7. Tetrahydrouridine
    ALA225973

    Name:
    2-(2,4'-bipyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]-pyridin-4-one

    Mol. Formula:
    C17H14N4O

    M.W.:
    290.33

    Type:
    Small molecule

    AlogP:
    2.42

    Polar Surface Area:
    70.67

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.76

    DETAILS
  8. Tetrahydrouridine
    ALA225975

    Name:
    2-(2,3'-bipyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]-pyridin-4-one

    Mol. Formula:
    C17H14N4O

    M.W.:
    290.33

    Type:
    Small molecule

    AlogP:
    2.42

    Polar Surface Area:
    70.67

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.76

    DETAILS
  9. Tetrahydrouridine
    ALA390601

    Name:
    2-(2-pyrimidin-5-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

    Mol. Formula:
    C16H13N5O

    M.W.:
    291.31

    Type:
    Small molecule

    AlogP:
    1.82

    Polar Surface Area:
    83.56

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.75

    DETAILS
  10. Tetrahydrouridine
    ALA388391

    Name:
    2-(2-thien-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one

    Mol. Formula:
    C16H13N3OS

    M.W.:
    295.37

    Type:
    Small molecule

    AlogP:
    3.09

    Polar Surface Area:
    57.78

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.76

    DETAILS