ID: ALA224
Type: SINGLE PROTEIN
Synonyms: 5-HT-2 | 5-HT-2A | 5-hydroxytryptamine receptor 2A | HTR2 | HTR2A | Serotonin receptor 2A
Organism: Homo sapiens
Species Group: Homo sapiens
Protein Target Classification: Membrane receptor / Family A G protein-coupled receptor / Small molecule receptor (family A GPCR) / Monoamine receptor / Serotonin receptor
ALA ID | Relationship | Pref Name | Target Type |
---|---|---|---|
ALA2096662 | SUBSET OF | Serotonin 2 receptors; 5-HT2a & 5-HT2c | SELECTIVITY GROUP |
ALA2095200 | SUBSET OF | Serotonin 2 (5-HT2) receptor | PROTEIN FAMILY |
ALA2111468 | SUBSET OF | Dopamine D2 receptor and serotonin 2a receptor | SELECTIVITY GROUP |
ALA4630758 | SUBSET OF | 5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 | PROTEIN COMPLEX |
ALA2096904 | SUBSET OF | Serotonin (5-HT) receptor | PROTEIN FAMILY |
Description | Relationship | Accession |
---|---|---|
5-hydroxytryptamine receptor 2A | PROTEIN | P28223 |
Name:
5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (4-methoxy-3-pyridin-3-yl-phenyl)-amide
Mol. Formula:
C23H20F3N3O3
M.W.:
443.43
Type:
Small molecule
AlogP:
5.38
Polar Surface Area:
63.69
HBA:
4
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.59
Name:
5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (3-fluoro-4-methyl-5-pyridin-3-yl-phenyl)-amide
Mol. Formula:
C23H19F4N3O2
M.W.:
445.42
Type:
Small molecule
AlogP:
5.82
Polar Surface Area:
54.46
HBA:
3
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
3
Passes Ro3:
N
QED Weighted:
0.52
Name:
5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (5-pyridin-3-yl-biphenyl-3-yl)-amide
Mol. Formula:
C28H22F3N3O2
M.W.:
489.50
Type:
Small molecule
AlogP:
7.04
Polar Surface Area:
54.46
HBA:
3
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.33
Name:
5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (4-methyl-3-pyridin-3-yl-phenyl)-amide
Mol. Formula:
C23H20F3N3O2
M.W.:
427.43
Type:
Small molecule
AlogP:
5.68
Polar Surface Area:
54.46
HBA:
3
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
3
Passes Ro3:
N
QED Weighted:
0.59
Name:
5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (3-ethyl-5-pyridin-3-yl-phenyl)-amide
Mol. Formula:
C24H22F3N3O2
M.W.:
441.45
Type:
Small molecule
AlogP:
5.93
Polar Surface Area:
54.46
HBA:
3
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.55
Name:
5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (3-bromo-5-pyridin-3-yl-phenyl)-amide
Mol. Formula:
C22H17BrF3N3O2
M.W.:
492.30
Type:
Small molecule
AlogP:
6.13
Polar Surface Area:
54.46
HBA:
3
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
3
Passes Ro3:
N
QED Weighted:
0.48
Name:
5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (3-fluoro-5-pyridin-3-yl-phenyl)-amide
Mol. Formula:
C22H17F4N3O2
M.W.:
431.39
Type:
Small molecule
AlogP:
5.51
Polar Surface Area:
54.46
HBA:
3
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
3
Passes Ro3:
N
QED Weighted:
0.56
Name:
5-Methylsulfanyl-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid pyridin-3-ylamide
Mol. Formula:
C16H14F3N3OS
M.W.:
353.37
Type:
Small molecule
AlogP:
4.42
Polar Surface Area:
45.23
HBA:
3
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
2
Passes Ro3:
N
QED Weighted:
0.81
Name:
5-Methylsulfanyl-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (3-pyridin-4-yl-phenyl)-amide
Mol. Formula:
C22H18F3N3OS
M.W.:
429.47
Type:
Small molecule
AlogP:
6.08
Polar Surface Area:
45.23
HBA:
3
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
3
Passes Ro3:
N
QED Weighted:
0.51