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Serotonin 2a (5-HT2a) receptor

Name And Classification

ID:  ALA224

Type:  SINGLE PROTEIN

Synonyms:   5-HT-2 | 5-HT-2A | 5-hydroxytryptamine receptor 2A | HTR2 | HTR2A | Serotonin receptor 2A

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Membrane receptor / Family A G protein-coupled receptor / Small molecule receptor (family A GPCR) / Monoamine receptor / Serotonin receptor

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA2096662SUBSET OFSerotonin 2 receptors; 5-HT2a & 5-HT2cSELECTIVITY GROUP
ALA2095200SUBSET OFSerotonin 2 (5-HT2) receptorPROTEIN FAMILY
ALA2111468SUBSET OFDopamine D2 receptor and serotonin 2a receptorSELECTIVITY GROUP
ALA4630758SUBSET OF5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2PROTEIN COMPLEX
ALA2096904SUBSET OFSerotonin (5-HT) receptorPROTEIN FAMILY

Target Components

DescriptionRelationshipAccession
5-hydroxytryptamine receptor 2APROTEINP28223

Associated Active Ligands

  1. Tetrahydrouridine
    ALA10780

    Name:
    2,2-Diphenyl-ethylamine

    Mol. Formula:
    C14H15N

    M.W.:
    197.28

    Type:
    Small molecule

    AlogP:
    2.78

    Polar Surface Area:
    26.02

    HBA:
    1

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    Y

    QED Weighted:
    0.80

    DETAILS
  2. Tetrahydrouridine
    ALA276571

    Name:
    5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (4-methoxy-3-pyridin-3-yl-phenyl)-amide

    Mol. Formula:
    C23H20F3N3O3

    M.W.:
    443.43

    Type:
    Small molecule

    AlogP:
    5.38

    Polar Surface Area:
    63.69

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.59

    DETAILS
  3. Tetrahydrouridine
    ALA280465

    Name:
    5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (3-fluoro-4-methyl-5-pyridin-3-yl-phenyl)-amide

    Mol. Formula:
    C23H19F4N3O2

    M.W.:
    445.42

    Type:
    Small molecule

    AlogP:
    5.82

    Polar Surface Area:
    54.46

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.52

    DETAILS
  4. Tetrahydrouridine
    ALA280297

    Name:
    5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (5-pyridin-3-yl-biphenyl-3-yl)-amide

    Mol. Formula:
    C28H22F3N3O2

    M.W.:
    489.50

    Type:
    Small molecule

    AlogP:
    7.04

    Polar Surface Area:
    54.46

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.33

    DETAILS
  5. Tetrahydrouridine
    ALA14606

    Name:
    5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (4-methyl-3-pyridin-3-yl-phenyl)-amide

    Mol. Formula:
    C23H20F3N3O2

    M.W.:
    427.43

    Type:
    Small molecule

    AlogP:
    5.68

    Polar Surface Area:
    54.46

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.59

    DETAILS
  6. Tetrahydrouridine
    ALA416896

    Name:
    5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (3-ethyl-5-pyridin-3-yl-phenyl)-amide

    Mol. Formula:
    C24H22F3N3O2

    M.W.:
    441.45

    Type:
    Small molecule

    AlogP:
    5.93

    Polar Surface Area:
    54.46

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.55

    DETAILS
  7. Tetrahydrouridine
    ALA14368

    Name:
    5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (3-bromo-5-pyridin-3-yl-phenyl)-amide

    Mol. Formula:
    C22H17BrF3N3O2

    M.W.:
    492.30

    Type:
    Small molecule

    AlogP:
    6.13

    Polar Surface Area:
    54.46

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.48

    DETAILS
  8. Tetrahydrouridine
    ALA14276

    Name:
    5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (3-fluoro-5-pyridin-3-yl-phenyl)-amide

    Mol. Formula:
    C22H17F4N3O2

    M.W.:
    431.39

    Type:
    Small molecule

    AlogP:
    5.51

    Polar Surface Area:
    54.46

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.56

    DETAILS
  9. Tetrahydrouridine
    ALA276140

    Name:
    5-Methylsulfanyl-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid pyridin-3-ylamide

    Mol. Formula:
    C16H14F3N3OS

    M.W.:
    353.37

    Type:
    Small molecule

    AlogP:
    4.42

    Polar Surface Area:
    45.23

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.81

    DETAILS
  10. Tetrahydrouridine
    ALA14841

    Name:
    5-Methylsulfanyl-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (3-pyridin-4-yl-phenyl)-amide

    Mol. Formula:
    C22H18F3N3OS

    M.W.:
    429.47

    Type:
    Small molecule

    AlogP:
    6.08

    Polar Surface Area:
    45.23

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.51

    DETAILS