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Acyl-CoA wax alcohol acyltransferase 2

Name And Classification

ID:  ALA2375204

Type:  SINGLE PROTEIN

Synonyms:   11-cis-RE-synthase | 11-cis-specific retinyl-ester synthase | 2.3.1.75 | 2.3.1.76 | Acyl-CoA retinol O-fatty-acyltransferase | Acyl-CoA wax alcohol acyltransferase 2 | ARAT | AWAT2 | DC4 | DGAT2L4 | Diacylglycerol O-acyltransferase 2-like protein 4 | Diacylglycerol O-acyltransferase candidate 4 | hDC4 | hWS | Long-chain-alcohol O-fatty-acyltransferase 2 | MFAT | Multifunctional O-acyltransferase | Retinol O-fatty-acyltransferase | Synonyms=DC4 | Wax synthase | WS

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Transferase

Target Components

DescriptionRelationshipAccession
Acyl-CoA wax alcohol acyltransferase 2PROTEINQ6E213

Associated Active Ligands

  1. Tetrahydrouridine
    ALA2376311

    Name:
    rac-3-ethyl-N,3-dimethyl-2,5-dioxo-N-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-sulfonamide

    Mol. Formula:
    C19H21N3O4S

    M.W.:
    387.46

    Type:
    Small molecule

    AlogP:
    2.36

    Polar Surface Area:
    95.58

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.84

    DETAILS
  2. Tetrahydrouridine
    ALA2376312

    Name:
    rac-N-(4-chlorophenyl)-3-ethyl-1,3-dimethyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-sulfonamide

    Mol. Formula:
    C19H20ClN3O4S

    M.W.:
    421.91

    Type:
    Small molecule

    AlogP:
    3.02

    Polar Surface Area:
    95.58

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.79

    DETAILS
  3. Tetrahydrouridine
    ALA2376313

    Name:
    rac-N-(2,4-difluorophenyl)-3-ethyl-3,4-dimethyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-sulfonamide

    Mol. Formula:
    C19H19F2N3O4S

    M.W.:
    423.44

    Type:
    Small molecule

    AlogP:
    2.96

    Polar Surface Area:
    95.58

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.79

    DETAILS
  4. Tetrahydrouridine
    ALA2376316

    Name:
    N-(2,4-difluorophenyl)-3,3-diethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-sulfonamide

    Mol. Formula:
    C19H21F2N3O3S

    M.W.:
    409.46

    Type:
    Small molecule

    AlogP:
    3.48

    Polar Surface Area:
    87.30

    HBA:
    4

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.71

    DETAILS
  5. Tetrahydrouridine
    ALA2376320

    Name:
    (S)-3-ethyl-3-methyl-2,5-dioxo-N-(4-(trifluoromethyl)phenyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-sulfonamide

    Mol. Formula:
    C19H18F3N3O4S

    M.W.:
    441.43

    Type:
    Small molecule

    AlogP:
    3.36

    Polar Surface Area:
    104.37

    HBA:
    4

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.68

    DETAILS
  6. Tetrahydrouridine
    ALA2376321

    Name:
    (S)-N-(4-(difluoromethoxy)phenyl)-3-ethyl-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-sulfonamide

    Mol. Formula:
    C19H19F2N3O5S

    M.W.:
    439.44

    Type:
    Small molecule

    AlogP:
    2.94

    Polar Surface Area:
    113.60

    HBA:
    5

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.64

    DETAILS
  7. Tetrahydrouridine
    ALA2376322

    Name:
    rac-3-ethyl-3-methyl-2,5-dioxo-N-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-sulfonamide

    Mol. Formula:
    C18H19N3O4S

    M.W.:
    373.43

    Type:
    Small molecule

    AlogP:
    2.34

    Polar Surface Area:
    104.37

    HBA:
    4

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.76

    DETAILS
  8. Tetrahydrouridine
    ALA2376325

    Name:
    rac-N-(4-chlorophenyl)-3-ethyl-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-sulfonamide

    Mol. Formula:
    C18H18ClN3O4S

    M.W.:
    407.88

    Type:
    Small molecule

    AlogP:
    2.99

    Polar Surface Area:
    104.37

    HBA:
    4

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.72

    DETAILS
  9. Tetrahydrouridine
    ALA2376327

    Name:
    rac-N-(2-chlorophenyl)-3-ethyl-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-sulfonamide

    Mol. Formula:
    C18H18ClN3O4S

    M.W.:
    407.88

    Type:
    Small molecule

    AlogP:
    2.99

    Polar Surface Area:
    104.37

    HBA:
    4

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.72

    DETAILS
  10. Tetrahydrouridine
    ALA2376329

    Name:
    rac-3-ethyl-N-(4-methoxyphenyl)-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-sulfonamide

    Mol. Formula:
    C19H21N3O5S

    M.W.:
    403.46

    Type:
    Small molecule

    AlogP:
    2.35

    Polar Surface Area:
    113.60

    HBA:
    5

    HBD:
    3

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.71

    DETAILS