ID: ALA240
Type: SINGLE PROTEIN
Synonyms: Eag homolog | Eag-related protein 1 | ERG | ERG-1 | ERG1 | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related protein 1 | H-ERG | HERG | hERG-1 | hERG1 | KCNH2 | Potassium voltage-gated channel subfamily H member 2 | Voltage-gated potassium channel subunit Kv11.1
Organism: Homo sapiens
Species Group: Homo sapiens
Protein Target Classification: Ion channel / Voltage-gated ion channel / Potassium channels / Voltage-gated potassium channel
ALA ID | Relationship | Pref Name | Target Type |
---|---|---|---|
ALA2362996 | SUBSET OF | Voltage-gated potassium channel | PROTEIN FAMILY |
ALA4106188 | SUBSET OF | Melanin-concentrating hormone receptor 2/HERG | SELECTIVITY GROUP |
Description | Relationship | Accession |
---|---|---|
Potassium voltage-gated channel subfamily H member 2 | PROTEIN | Q12809 |
Name:
N-[4-(2-{[2-(4-Methanesulfonylamino-phenyl)-ethyl]-methyl-amino}-ethoxy)-phenyl]-methanesulfonamide
Mol. Formula:
C19H27N3O5S2
M.W.:
441.58
Type:
Small molecule
AlogP:
1.98
Polar Surface Area:
104.81
HBA:
6
HBD:
2
#RO5 Violations:
0
#Rotatable Bonds:
11
Passes Ro3:
N
QED Weighted:
0.55
Name:
5-Chloro-1-(4-fluoro-phenyl)-3-piperidin-4-yl-1H-indole
Mol. Formula:
C19H18ClFN2
M.W.:
328.82
Type:
Small molecule
AlogP:
4.89
Polar Surface Area:
16.96
HBA:
2
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
2
Passes Ro3:
N
QED Weighted:
0.71
Name:
1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-3,6-dihydro-2H-pyridin-1-yl}-ethyl)-imidazolidin-2-one
Mol. Formula:
C24H24ClFN4O
M.W.:
438.93
Type:
Small molecule
AlogP:
4.54
Polar Surface Area:
40.51
HBA:
3
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
5
Passes Ro3:
N
QED Weighted:
0.64
Name:
1-(4-tert-Butyl-phenyl)-4-[4-(hydroxy-diphenyl-methyl)-piperidin-1-yl]-butan-1-ol
Mol. Formula:
C32H41NO2
M.W.:
471.69
Type:
Small molecule
AlogP:
6.45
Polar Surface Area:
43.70
HBA:
3
HBD:
2
#RO5 Violations:
1
#Rotatable Bonds:
8
Passes Ro3:
N
QED Weighted:
0.40
Name:
5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-1,3-dihydro-indol-2-one
Mol. Formula:
C21H21ClN4OS
M.W.:
412.95
Type:
Small molecule
AlogP:
3.81
Polar Surface Area:
48.47
HBA:
5
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.71
Name:
8-Chloro-11-piperazin-1-yl-5H-dibenzo[b,e][1,4]diazepine
Mol. Formula:
C17H17ClN4
M.W.:
312.80
Type:
Small molecule
AlogP:
3.38
Polar Surface Area:
39.66
HBA:
4
HBD:
2
#RO5 Violations:
0
#Rotatable Bonds:
0
Passes Ro3:
N
QED Weighted:
0.78
Name:
4-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-1-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-butan-1-ol
Mol. Formula:
C31H39NO3
M.W.:
473.66
Type:
Small molecule
AlogP:
5.38
Polar Surface Area:
63.93
HBA:
4
HBD:
3
#RO5 Violations:
1
#Rotatable Bonds:
9
Passes Ro3:
N
QED Weighted:
0.39
Name:
1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidine-2-thione
Mol. Formula:
C24H27FN4S
M.W.:
422.57
Type:
Small molecule
AlogP:
4.55
Polar Surface Area:
23.77
HBA:
4
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
5
Passes Ro3:
N
QED Weighted:
0.61
Name:
4-(5-Chloro-3-{1-[2-(2-oxo-imidazolidin-1-yl)-ethyl]-piperidin-4-yl}-indol-1-yl)-benzoic acid methyl ester
Mol. Formula:
C26H29ClN4O3
M.W.:
481.00
Type:
Small molecule
AlogP:
4.28
Polar Surface Area:
66.81
HBA:
5
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
6
Passes Ro3:
N
QED Weighted:
0.53
Name:
1-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-ethanone
Mol. Formula:
C16H11ClFNO
M.W.:
287.72
Type:
Small molecule
AlogP:
4.63
Polar Surface Area:
22.00
HBA:
2
HBD:
0
#RO5 Violations:
0
#Rotatable Bonds:
2
Passes Ro3:
N
QED Weighted:
0.63