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Serine/threonine-protein kinase Chk2

Name And Classification

ID:  ALA2527

Type:  SINGLE PROTEIN

Synonyms:   2.7.11.1 | CDS1 | Cds1 homolog | Checkpoint kinase 2 | CHEK2 | CHK2 | CHK2 checkpoint homolog | hCds1 | Hucds1 | RAD53 | Serine/threonine-protein kinase Chk2

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Kinase / Protein Kinase / CAMK protein kinase group / CAMK protein kinase RAD53 family

Target Relations

ALA IDRelationshipPref NameTarget Type
ALA3883296SUBSET OFSerine/threonine-protein kinase Chk1/2PROTEIN FAMILY

Target Components

DescriptionRelationshipAccession
Serine/threonine-protein kinase Chk2PROTEINO96017

Associated Active Ligands

  1. Tetrahydrouridine
    ALA176235

    Name:
    2-(3-Phenoxy-phenyl)-1H-benzoimidazole-5-carboxylic acid amide

    Mol. Formula:
    C20H15N3O2

    M.W.:
    329.36

    Type:
    Small molecule

    AlogP:
    4.12

    Polar Surface Area:
    81.00

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.59

    DETAILS
  2. Tetrahydrouridine
    ALA176115

    Name:
    2-p-Tolyl-1H-benzoimidazole-5-carboxylic acid amide

    Mol. Formula:
    C15H13N3O

    M.W.:
    251.29

    Type:
    Small molecule

    AlogP:
    2.64

    Polar Surface Area:
    71.77

    HBA:
    2

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.73

    DETAILS
  3. Tetrahydrouridine
    ALA176326

    Name:
    2-Naphthalen-2-yl-1H-benzoimidazole-5-carboxylic acid amide

    Mol. Formula:
    C18H13N3O

    M.W.:
    287.32

    Type:
    Small molecule

    AlogP:
    3.48

    Polar Surface Area:
    71.77

    HBA:
    2

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.59

    DETAILS
  4. Tetrahydrouridine
    ALA175676

    Name:
    2-[3-(3,4-Dichloro-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide

    Mol. Formula:
    C20H13Cl2N3O2

    M.W.:
    398.25

    Type:
    Small molecule

    AlogP:
    5.43

    Polar Surface Area:
    81.00

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.48

    DETAILS
  5. Tetrahydrouridine
    ALA176276

    Name:
    2-(4-Phenoxy-phenyl)-1H-benzoimidazole-4-carboxylic acid amide

    Mol. Formula:
    C20H15N3O2

    M.W.:
    329.36

    Type:
    Small molecule

    AlogP:
    4.12

    Polar Surface Area:
    81.00

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.59

    DETAILS
  6. Tetrahydrouridine
    ALA176041

    Name:
    2-Phenyl-1H-benzoimidazole-5-carboxylic acid amide

    Mol. Formula:
    C14H11N3O

    M.W.:
    237.26

    Type:
    Small molecule

    AlogP:
    2.33

    Polar Surface Area:
    71.77

    HBA:
    2

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.72

    DETAILS
  7. Tetrahydrouridine
    ALA175780

    Name:
    2-(4-Ethoxy-phenyl)-1H-benzoimidazole-5-carboxylic acid amide

    Mol. Formula:
    C16H15N3O2

    M.W.:
    281.32

    Type:
    Small molecule

    AlogP:
    2.73

    Polar Surface Area:
    81.00

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.77

    DETAILS
  8. Tetrahydrouridine
    ALA367390

    Name:
    2-(4-Phenoxy-phenyl)-1H-benzoimidazole-5-carboxylic acid

    Mol. Formula:
    C20H14N2O3

    M.W.:
    330.34

    Type:
    Small molecule

    AlogP:
    4.72

    Polar Surface Area:
    75.21

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.57

    DETAILS
  9. Tetrahydrouridine
    ALA176554

    Name:
    2-(4-Phenoxy-phenyl)-1H-benzoimidazole-5-carbonitrile

    Mol. Formula:
    C20H13N3O

    M.W.:
    311.34

    Type:
    Small molecule

    AlogP:
    4.89

    Polar Surface Area:
    61.70

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.59

    DETAILS
  10. Tetrahydrouridine
    ALA175481

    Name:
    5-Nitro-2-(4-phenoxy-phenyl)-1H-benzoimidazole

    Mol. Formula:
    C19H13N3O3

    M.W.:
    331.33

    Type:
    Small molecule

    AlogP:
    4.93

    Polar Surface Area:
    81.05

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.42

    DETAILS