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Ribosomal protein S6 kinase alpha 1

Name And Classification

ID:  ALA2553

Type:  SINGLE PROTEIN

Synonyms:   2.7.11.1 | 90 kDa ribosomal protein S6 kinase 1 | MAP kinase-activated protein kinase 1a | MAPK-activated protein kinase 1a | MAPKAP kinase 1a | MAPKAPK-1a | MAPKAPK1A | p90-RSK 1 | p90RSK1 | p90S6K | Ribosomal protein S6 kinase alpha-1 | Ribosomal S6 kinase 1 | RPS6KA1 | RSK-1 | RSK1 | S6K-alpha-1

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Enzyme / Kinase / Protein Kinase / AGC protein kinase group / AGC protein kinase RSK family / AGC protein kinase RSK subfamily

Target Relations

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ALA IDRelationshipPref NameTarget Type

Target Components

DescriptionRelationshipAccession
Ribosomal protein S6 kinase alpha-1PROTEINQ15418

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Antibodies

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NameSpecificationsSpecies reactivityspeciesApplicationView Details

Associated Active Ligands

  1. Tetrahydrouridine
    ALA573107

    Name:
    2-((3,5-difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one

    Mol. Formula:
    C19H23F2N5O2

    M.W.:
    391.42

    Type:
    Small molecule

    AlogP:
    3.42

    Polar Surface Area:
    81.59

    HBA:
    6

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.76

    DETAILS
  2. Tetrahydrouridine
    ALA577784

    Name:
    N-(3-((5-iodo-4-((3-(thiophene-2-carboxamido)propyl)amino)pyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide

    Mol. Formula:
    C23H26IN7O2S

    M.W.:
    591.48

    Type:
    Small molecule

    AlogP:
    4.75

    Polar Surface Area:
    111.28

    HBA:
    7

    HBD:
    4

    #RO5 Violations:
    1

    #Rotatable Bonds:
    9

    Passes Ro3:
    N

    QED Weighted:
    0.21

    DETAILS
  3. Tetrahydrouridine
    ALA569545

    Name:
    3-(2-aminoethyl)-5-(2-ethoxybenzylidene)thiazolidine-2,4-dione

    Mol. Formula:
    C14H16N2O3S

    M.W.:
    292.36

    Type:
    Small molecule

    AlogP:
    2.08

    Polar Surface Area:
    72.63

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.84

    DETAILS
  4. Tetrahydrouridine
    ALA569743

    Name:
    3-(2-aminoethyl)-5-(4-fluorobenzylidene)thiazolidine-2,4-dione

    Mol. Formula:
    C12H11FN2O2S

    M.W.:
    266.30

    Type:
    Small molecule

    AlogP:
    1.82

    Polar Surface Area:
    63.40

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.85

    DETAILS
  5. Tetrahydrouridine
    ALA577953

    Name:
    3-(2-aminoethyl)-5-(3-fluorobenzylidene)thiazolidine-2,4-dione

    Mol. Formula:
    C12H11FN2O2S

    M.W.:
    266.30

    Type:
    Small molecule

    AlogP:
    1.82

    Polar Surface Area:
    63.40

    HBA:
    4

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.85

    DETAILS
  6. Tetrahydrouridine
    ALA576895

    Name:
    3-(2-aminoethyl)-5-(4-nitrobenzylidene)thiazolidine-2,4-dione

    Mol. Formula:
    C12H11N3O4S

    M.W.:
    293.30

    Type:
    Small molecule

    AlogP:
    1.59

    Polar Surface Area:
    106.54

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.51

    DETAILS
  7. Tetrahydrouridine
    ALA570003

    Name:
    3-(2-aminoethyl)-5-(3-nitrobenzylidene)thiazolidine-2,4-dione

    Mol. Formula:
    C12H11N3O4S

    M.W.:
    293.30

    Type:
    Small molecule

    AlogP:
    1.59

    Polar Surface Area:
    106.54

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.51

    DETAILS
  8. Tetrahydrouridine
    ALA577105

    Name:
    3-(2-(dimethylamino)ethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione

    Mol. Formula:
    C16H20N2O3S

    M.W.:
    320.41

    Type:
    Small molecule

    AlogP:
    2.68

    Polar Surface Area:
    49.85

    HBA:
    5

    HBD:
    0

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.75

    DETAILS
  9. Tetrahydrouridine
    ALA570425

    Name:
    N-(2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)ethyl)acetamide

    Mol. Formula:
    C16H18N2O4S

    M.W.:
    334.40

    Type:
    Small molecule

    AlogP:
    2.26

    Polar Surface Area:
    75.71

    HBA:
    5

    HBD:
    1

    #RO5 Violations:
    0

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.81

    DETAILS
  10. Tetrahydrouridine
    ALA3975634

    Name:
    US8889696, Staurosporine::US9051313, Staurosporine

    Mol. Formula:
    C27H24N4O3

    M.W.:
    452.51

    Type:
    Small molecule

    AlogP:
    4.75

    Polar Surface Area:
    72.94

    HBA:
    6

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.41

    DETAILS